Single-cell transcriptomics reveals spatial and temporal turnover of keratinocyte differentiation regulators

A Finnegan, RJ Cho, A Luu, P Harirchian, J Lee… - Frontiers in …, 2019 - frontiersin.org
… that specify epidermis structure and function. This article utilizes single-cell RNA-seq data
… transcriptional regulation of skin development and homeostasis genes, organizing them by …

Single cell transcriptomics of human epidermis identifies basal stem cell transition states

S Wang, ML Drummond, CF Guerrero-Juarez… - Nature …, 2020 - nature.com
single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular
epidermis and find four spatially … specific gene expression signatures that are strongly …

[HTML][HTML] Single-cell transcriptome profiling reveals dermal and epithelial cell fate decisions during embryonic hair follicle development

W Ge, SJ Tan, SH Wang, L Li, XF Sun, W Shen… - Theranostics, 2020 - ncbi.nlm.nih.gov
… , we for the first time revealed the dermal and epidermal cell lineage … signatures of embryonic
hair follicle progenitors using unbiased scRNA-seq. Based on single-cell transcriptome

[PDF][PDF] Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics

D Haensel, S Jin, P Sun, R Cinco, M Dragan… - Cell reports, 2020 - cell.com
… Using single-cell RNA sequencing coupled with RNAScope … skin that differ in metabolic
preference and become spatially … response) and EMT signatures in WO basal cells (Figure 3C). …

Integrating SingleCell and Spatial Transcriptomics Reveals Heterogeneity of Early Pig Skin Development and a Subpopulation with Hair Placode Formation

Y Wang, Y Jiang, G Ni, S Li, B Balderson… - Advanced …, 2024 - Wiley Online Library
… In this study, we generated single-cell and spatial transcriptomes of fetal pig skin during …
and spatial positions, we created an integrated transcriptome atlas of the entire embryonic skin

Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic Cells

K Thrane, MCG Winge, H Wang, L Chen… - Journal of Investigative …, 2023 - Elsevier
… 0.82 for granular cells), further supporting their early differentiating status (Supplementary
Figure S5f). Examination of the spinous II signature in pseudotime revealed that signature

Single cell transcriptomics of human epidermis reveals basal stem cell transition states

S Wang, ML Drummond, CF Guerrero-Juarez… - bioRxiv, 2019 - biorxiv.org
single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular
epidermis and find at least four spatially … specific gene expression signatures that are …

[HTML][HTML] Single-cell transcriptomics reveals the molecular anatomy of sheep hair follicle heterogeneity and wool curvature

S Wang, T Wu, J Sun, Y Li, Z Yuan… - Frontiers in Cell and …, 2021 - frontiersin.org
… and revealed the differentiation and spatial signatures underlying … We detected 19,097
genes in skin cells for the straight wool … After QC, we obtained 15,830 single-cell transcriptome

[PDF][PDF] Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

T Krausgruber, A Redl, D Barreca, K Doberer… - Immunity, 2023 - cell.com
… and non-lesional skin by using gene signatures derived from our … skin granulomas, we
performed dimensionality reduction and unsupervised clustering of the single-cell transcriptome

Singlecell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts

QM Phan, S Sinha, J Biernaskie… - Experimental …, 2021 - Wiley Online Library
… type shares a similar gene signature to the murine … skin regeneration. The WIHN model
system has been utilized in studies to reveal the importance of epidermal stem cell differentiation