… Catechol-O-methyltransferase (COMT) inhibitors modulate cortical dopaminergic function
and have been proposed as potential cognitive enhancers. Unfortunately, currently available …

… Catechol-O-methyltransferase (COMT) is an important enzyme involved in the metabolic
inactivation of the dopamine … COMT inactivates dopamine in prefrontal cortex region of brain …

… Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal
… For instance, the catechol-O-methyltransferase (COMT) Val158Met polymorphism gives …

… The availability of DA and NE in the prefrontal cortex is mainly affected by COMT enzymes
[ 56 ]. Recent research showed that altered dopaminergic and noradrenergic tone, affected by …

… Decades of evidence across taxa have established the importance of dopamine (DA) … using
the catechol-o-methyltransferase (COMT) gene as a proxy for basal prefrontal DA tone. The …

… particularly by catechol-O-methyltransferase (COMT), is more prominent in prefrontal cortex
(… These results, however, contrast with a report of differences in dopamine overflow in COMT …

… ’s effects on dopamine metabolism in the brain (including in subcortical and prefrontal cortical
… only in higher basal synaptic dopamine levels (primarily in the prefrontal cortex (PFC) but …

… , dopamine in the prefrontal cortex heavily influences the stability of mental representations
during working memory tasks, yet no research has probed its role in … role of dopamine on the …

… The catechol-O-methyl transferase (COMT) enzyme is primarily responsible for the breakdown
of dopamine (DA) in the prefrontal cortex (PFC), and thereby termination of dopaminergic …

… Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism
… In prefrontal cortex (PF), COMT mainly controls the dopaminergic transmission, because …