The role of mitochondrial reactive oxygen species in insulin resistance

A Ayer, DJ Fazakerley, DE James, R Stocker - Free Radical Biology and …, 2022 - Elsevier
role for mitochondrial reactive oxygen species in the etiology of insulin resistance in adipose
tissue and skeletal muscle… the sources and nature of various mitochondrial reactive oxygen …

[HTML][HTML] Mitochondrial activity and skeletal muscle insulin resistance in kidney disease

JE Carré, C Affourtit - International journal of molecular sciences, 2019 - mdpi.com
… It is unclear if added antioxidants are able to reach the ROS sources, which complicates the
… bioenergetics that raise ROS generation sufficiently to impair muscle insulin signalling [54]. …

Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

SM Frangos, DJ Bishop, GP Holloway - Biochemical Journal, 2021 - portlandpress.com
… of reactive lipid- and ROS-dependent skeletal muscle insulin resistance. This is … source of
ROS (mitochondrial vs cytosolic) may have different effects on skeletal muscle insulin sensitivity

[HTML][HTML] Mechanism of increased risk of insulin resistance in aging skeletal muscle

J Shou, PJ Chen, WH Xiao - Diabetology & metabolic syndrome, 2020 - Springer
Mitochondria are the main source of skeletal muscle ROS and are involved in the regulation
of various physiological functions of skeletal muscle. At normal concentrations, ROS activate …

[HTML][HTML] Are alterations in skeletal muscle mitochondria a cause or consequence of insulin resistance?

AJ Genders, GP Holloway, DJ Bishop - International Journal of Molecular …, 2020 - mdpi.com
role for mitochondria in the development of insulin resistance. … role of altered substrate
oxidation by the mitochondria as a … An increase in ROS emission from the mitochondria has also …

Role of skeletal muscle lipids in the pathogenesis of insulin resistance of obesity and type 2 diabetes

M Gilbert - Journal of diabetes investigation, 2021 - Wiley Online Library
… availability for other tissues, namely skeletal muscle, which uses them as a fuel source for
… on the respective role of lipid metabolites, mitochondria, oxidative stress/ROS, inflammation …

[HTML][HTML] The mitochondrial proteomic signatures of human skeletal muscle linked to insulin resistance

R Kruse, N Sahebekhtiari, K Højlund - International Journal of Molecular …, 2020 - mdpi.com
… of skeletal muscle proteome. Area covered: Here, we review the currently available studies
… the mitochondrial proteome in human skeletal muscle in insulin-resistant conditions, such …

Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
skeletal muscle insulin resistance, resulting in a decrease in … whether or not muscle
mitochondrial ROS production directly … inability to switch fuel sources that can consequently …

TFAM enhances fat oxidation and attenuates high-fat diet–induced insulin resistance in skeletal muscle

JH Koh, ML Johnson, S Dasari, NK LeBrasseur… - Diabetes, 2019 - Am Diabetes Assoc
mitochondria to act as a ROS scavenger, and found that activated AMPK binds to Cyt c (Fig.
3J). The net effect of reduced ROS … preference of FA as the energy source in TFAM muscle. …

[HTML][HTML] Mitochondrial function and reactive oxygen/nitrogen species in skeletal muscle

MM Chen, Y Li, SL Deng, Y Zhao, ZX Lian… - Frontiers in Cell and …, 2022 - frontiersin.org
skeletal muscle mitochondria, we will review the origin and physiological function of RONS,
mitochondrial structure and function, … Skeletal muscle has several sources of ROS, multiple …