Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine

F Musaigwa - 2022 - open.uct.ac.za
… (vaccine) specific antibodies, and wait for antigen activated recall responses that trigger
a rapid production of antibodies. B. Type 1 vaccine immune response: DCs are activated by …

[HTML][HTML] Sex—the most underappreciated variable in research: insights from helminth-infected hosts

A Wesołowska - Veterinary Research, 2022 - Springer
… sex is known to influence the response to vaccines. Despite its … bias in the case of helminth
infection. The precise nature of the … Schistosoma mansoni infection is suppressed by elevated …

[HTML][HTML] The role of helminths in the development of non-communicable diseases

Y Wu, M Duffey, SE Alex, C Suarez-Reyes… - Frontiers in …, 2022 - frontiersin.org
… potential drivers of NCDs in parasite-endemic regions. Though understudied, the impact of
helminth infections on the development of NCDs is likely related to helminth-specific factors, …

[HTML][HTML] Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review

BW Bullington, K Klemperer, K Mages, A Chalem… - PLoS …, 2021 - journals.plos.org
… B vaccine response may be compromised by schistosome infection and … worm infection,
attenuated anti-gp140 antibody responses [55]. Another study reported that S. mansoni infection

[HTML][HTML] Whipworm and roundworm infections

KJ Else, J Keiser, CV Holland, RK Grencis… - Nature Reviews …, 2020 - nature.com
… areas are typical of soil-transmitted helminths (STHs). There is evidence from some, but not
all, … compromising the integrity of the gut barrier. The pre-patent period (that is, the time from …

Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice

MJ Girasol, LR Grecia, JC Fabi, AJ Fernandez… - Experimental …, 2021 - Elsevier
… high global prevalence of soil transmitted helminthiasis, no … , infection) did not elicit a much
greater IgG antibody response … post-infection because by doing so, a compromise is reached …

[PDF][PDF] Antigen specificity of the adaptive immune response against helminths

N Thuma - 2022 - opus4.kobv.de
soil-transmitted) with infections mainly occurring in subtropical areas and regions with poor
sanitation. Soil-transmitted helminths … of a non-specific antibody response during Nb infection

[HTML][HTML] Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro

T Adjobimey, J Meyer, V Terkeš, M Parcina, A Hoerauf - BMC medicine, 2022 - Springer
… Modulation of SARS-CoV-2-reactive CD4 + and CD8 + T cells is associated with an increase
of IL-10 To explore the mechanisms associated with this immune suppression by helminth

Intestinal helminth infection impairs oral and parenteral vaccine efficacy

LKC Hardy, CM Kapita, E Campbell, JA Hall… - bioRxiv, 2022 - biorxiv.org
… Heligmosomoides polygyrus bakeri significantly suppressed Th1-skewed OVA-specific
antibody responses to our live attenuated oral Salmonella-OVA vaccine (Fig. 4). Strikingly, …

Altered offspring immunity in maternal parasitic infections

LC Gibbs, KC Fairfax - The Journal of Immunology, 2022 - journals.aai.org
… currently at risk for infection by soil-transmitted helminths (6) and ∼… that anti-measles Abs
remain suppressed at 2 y of age in … on children’s IgG antibody responses to routine vaccines 2 …