… was accompanied by lower levels of mature β-glucocerebrosidase protein and accumulation
of … However, further research is needed to determine if the readthrough protein is fully …

… encoding progranulin (PGRN), were identified in patients with frontotemporal lobar degeneration
(… linked to reduced PGRN protein expression levels. Although initial characterization of …

… To further determine the role of PSAP in PGRN processing in vivo, we examined the levels
of … project to cure frontotemporal dementia to FH The funders are not involved in the study. …

… We next determined whether latozinemab alters the endogenous levels of sortilin in human
U251 cells. Latozinemab was found to reduce cell surface expression of sortilin in a dose-…

… The risk haplotype at the GFRA2 locus is associated with lower mRNA levels of GFRA2 in
brain tissue as compared to the protective haplotype. Moreover, we determined that PGRN …

… ceroid lipofuscinosis or frontotemporal dementia-GRN (FTD-… PGRN levels increase the risk
for developing Alzheimer’s … PGRN levels in FTD-GRN may help determine whether dementia …

… Behavioral variant frontotemporal dementia (bvFTD) is the most common clinical … Extracellular
GRN levels are regulated through endocytosis and proteolytic degradation. Individual six …

… of proteolytic enzymes with progranulin loss. Subsequently, I … this endeavor as their first
dualdegree graduate student. To Dr. … Intriguingly, clinical symptoms are not determined by the …

… causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could …
We then determined the binding region of mAbs of each epitope bin in the following epitope …

… sclerosis (ALS) and frontotemporal dementia (FTLD) patients … and protein content may
determine changes in extracellular … of the intracellular progranulin protein levels both in murine …