[HTML][HTML] New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia
S Amin, G Carling, L Gan - Current Opinion in Neurobiology, 2022 - Elsevier
… was accompanied by lower levels of mature β-glucocerebrosidase protein and accumulation
of … However, further research is needed to determine if the readthrough protein is fully …
of … However, further research is needed to determine if the readthrough protein is fully …
[HTML][HTML] Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia
MJ Simon, T Logan, SL DeVos, G Di Paolo - Trends in Cell Biology, 2023 - cell.com
… encoding progranulin (PGRN), were identified in patients with frontotemporal lobar degeneration
(… linked to reduced PGRN protein expression levels. Although initial characterization of …
(… linked to reduced PGRN protein expression levels. Although initial characterization of …
Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin
… To further determine the role of PSAP in PGRN processing in vivo, we examined the levels
of … project to cure frontotemporal dementia to FH The funders are not involved in the study. …
of … project to cure frontotemporal dementia to FH The funders are not involved in the study. …
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia
M Kurnellas, A Mitra, T Schwabe, R Paul… - Journal of Translational …, 2023 - Springer
… We next determined whether latozinemab alters the endogenous levels of sortilin in human
U251 cells. Latozinemab was found to reduce cell surface expression of sortilin in a dose-…
U251 cells. Latozinemab was found to reduce cell surface expression of sortilin in a dose-…
Lysosomal dysfunction and other pathomechanisms in FTLD: evidence from progranulin genetics and biology
… The risk haplotype at the GFRA2 locus is associated with lower mRNA levels of GFRA2 in
brain tissue as compared to the protective haplotype. Moreover, we determined that PGRN …
brain tissue as compared to the protective haplotype. Moreover, we determined that PGRN …
Progranulin as a therapeutic target in neurodegenerative diseases
… ceroid lipofuscinosis or frontotemporal dementia-GRN (FTD-… PGRN levels increase the risk
for developing Alzheimer’s … PGRN levels in FTD-GRN may help determine whether dementia …
for developing Alzheimer’s … PGRN levels in FTD-GRN may help determine whether dementia …
Tweaking progranulin expression: therapeutic avenues and opportunities
J Terryn, CM Verfaillie, P Van Damme - Frontiers in Molecular …, 2021 - frontiersin.org
… Behavioral variant frontotemporal dementia (bvFTD) is the most common clinical … Extracellular
GRN levels are regulated through endocytosis and proteolytic degradation. Individual six …
GRN levels are regulated through endocytosis and proteolytic degradation. Individual six …
Lysosome Dynamics in Models of Frontotemporal Dementia and Alzheimer's Disease
S Hasan - 2023 - discovery.ucl.ac.uk
… of proteolytic enzymes with progranulin loss. Subsequently, I … this endeavor as their first
dualdegree graduate student. To Dr. … Intriguingly, clinical symptoms are not determined by the …
dualdegree graduate student. To Dr. … Intriguingly, clinical symptoms are not determined by the …
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
S Miyakawa, H Sakuma, D Warude… - Frontiers in …, 2020 - frontiersin.org
… causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could …
We then determined the binding region of mAbs of each epitope bin in the following epitope …
We then determined the binding region of mAbs of each epitope bin in the following epitope …
Inter-Species Differences in Regulation of the Progranulin–Sortilin Axis in TDP-43 Cell Models of Neurodegeneration
V Gumina, E Onesto, C Colombrita… - International Journal of …, 2019 - mdpi.com
… sclerosis (ALS) and frontotemporal dementia (FTLD) patients … and protein content may
determine changes in extracellular … of the intracellular progranulin protein levels both in murine …
determine changes in extracellular … of the intracellular progranulin protein levels both in murine …