… Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental
disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far been …

… with schizophrenia more closely resemble the foetal state 44 . … and axonogenesis in the
human prefrontal cortex (PFC) 58 . … crosstalk between de novo gene methylation and foetal brain …

… dorsolateral prefrontal cortex, VFC ventrolateral prefrontal … , STC superior temporal cortex,
ITC inferior temporal cortex, V1C … in the human brain during the fetal period (described above), …

… Expression levels of more than 12,000 genes rise or fall in a concerted late-fetal transition,
with the transitional genes enriched for cell-type-specific genes and neuropsychiatric risk loci, …

… of the prefrontal cortex in schizophrenia patient tissue … origin of schizophrenia in the Roman
rat strains, we mapped the … human samples, ranging from foetal development (negative ages…

… de novo mutations in the disorder were most significantly coexpressed in the frontal cortex
during fetal … of the corresponding genes in the prefrontal cortex during the second trimester of …

… for each fetal brain cell population. The function map.snps.to.genes was run to map single
… genetic association with schizophrenia in cells of the second-trimester fetal brain, we first …

… in the human dorsolateral prefrontal cortex (DLPFC), and the … a wave of change in fetuses,
most miRNAs are preferentially … We selected only the de novo mutations from patients and …

… available foetal tissues (E081=foetal brain female and E082 = foetal … inferior temporal lobe
and E073 = brain dorsolateral prefrontal … The 3D chromatin interaction mapping was built-in …

… In particular, the extensive usage of WES in research studies has uncovered the important
contribution of de novo mutations (DNMs) to these disorders. Trio and quad familial WES are …