Aquaporin 5 in the eye: expression, function, and roles in ocular diseases

K Zhang, G Di, Y Bai, A Liu, W Bian, P Chen - Experimental Eye Research, 2023 - Elsevier
cornea and the associated regulation of AQP5 in the corneal … The mammalian lens mainly
consists of two types of cells: … The body may regulate the localization and expression of AQP5

Lens aquaporins in health and disease: Location is everything!

KL Schey, RB Gletten, CVT O'Neale, Z Wang… - Frontiers in …, 2022 - frontiersin.org
… the lens. This review discusses the structure and function of lens AQPs and, importantly, their
spatial localization … -sensing TRP channels can regulate AQP5 localization in the equatorial …

Regulation of water flow in the ocular lens: new roles for aquaporins

PJ Donaldson, RS Petrova, N Nair… - The Journal of …, 2024 - Wiley Online Library
… In mammals the crystalline lens is an avascular, multi-cellular, … the spatial order in the outer
cortex of the lens through the … localization and post-translational modification of lens AQPs …

Aquaporin-5 expression, trafficking, and interacting partners in the bovine lens

RB Gletten - 2022 - search.proquest.com
… patterns, subcellular localization, trafficking mechanisms, and … eye, AQP5 is significantly
expressed in the cornea where it … mechanisms of AQP regulation in mammals and additional …

Aquaporins in the Cornea

S Melnyk, WB Bollag - International Journal of Molecular Sciences, 2024 - mdpi.com
mammals, the main AQPs with conserved expression in the cornea of different species are
AQP1, AQP3, and AQP5… been known to regulate AQP5 expression, as well as localization, as …

[HTML][HTML] Altered expression of aquaporin 1 and aquaporin 5 in the cornea after primary blast exposure

JD Ríos, JH Choi, JS McDaniel, S Becera, L Bice… - Molecular …, 2019 - ncbi.nlm.nih.gov
localization of AQP1 and AQP5 in the cornea after blast … and cytoplasmic expression in the
corneal epithelium of control … the cornea and the lens or iris before the cornea returns to its

Changes to zonular tension alters the subcellular distribution of AQP5 in regions of influx and efflux of water in the rat lens

RS Petrova, N Bavana, R Zhao… - … & Visual Science, 2020 - iovs.arvojournals.org
… The drugs were diluted in AAH and applied to the corneallocalization of AQP5 in the efflux
zone of the rat lens. (A) … and AQP5 labeling from control lenses (B) and lenses incubated in …

Aquaporin-5 dynamic regulation

C D'Agostino, D Parisis, C Chivasso… - International journal of …, 2023 - mdpi.com
… acid, increased the AQP5 expression in corneal cells and lacrimal … In bovine and other
mammalian lenses, AQP5 trafficking … differentiating lens fiber, while its localization shifted to lens

[HTML][HTML] Aquaporin 5 facilitates corneal epithelial wound healing and nerve regeneration by reactivating Akt signaling pathway

Y Liu, G Di, Y Wang, D Chong, X Cao… - The American journal of …, 2021 - Elsevier
… In mammals, 13 kinds of aquaporins (AQP0 to AQP12) have … , the expression of AQP5 in
the cornea is up-regulated, and its … the localization and expression of AQP5 in mouse cornea, …

Aquaporins in Eye

TL Tran, S Hamann, S Heegaard - Aquaporins, 2023 - Springer
… many metabolic products of corneal-, ciliary body-, lens-, and retinal … during shifts in the
spatial location of the lens fibers [22]. … AQP5 may therefore regulate the osmolality of tears rather …