Genome‐wide analysis of acute traumatic spinal cord injury‐related RNA expression profiles and uncovering of a regulatory axis in spinal fibrotic scars

W Wang, J Li, Z Zhang, H Ma, Q Li, H Yang… - Cell …, 2021 - Wiley Online Library
… critical for posttranscriptional and transcriptional regulation in … spinal tissues after acute
traumatic spinal cord injury (ATSCI) are scarce. We aimed to identify lncRNA expression profiles

[HTML][HTML] Specific blood RNA profiles in individuals with acute spinal cord injury as compared with trauma controls

Q Chen, L Wang, H Wu, C Ye, D Xie, Q Zhao… - … Medicine and Cellular …, 2023 - hindawi.com
… by various traffic accidents and violent injuries, spinal cord … , RNA-seq datasets related to
the spinal cord tissues and blood samples after acute SCI were used for bioinformatic analysis

Signatures of altered long noncoding RNAs and messenger RNAs expression in the early acute phase of spinal cord injury

Z Shi, G Ning, B Zhang, S Yuan, H Zhou… - Journal of Cellular …, 2019 - Wiley Online Library
… To examine the dysregulated lncRNA expression signatures in injured spinal cord, we
analyzed upregulated and downregulated lncRNAs according length distribution and …

[HTML][HTML] A transcriptomic meta-analysis shows lipid metabolism dysregulation as an early pathological mechanism in the spinal cord of SOD1 mice

LC Fernández-Beltrán, JM Godoy-Corchuelo… - International journal of …, 2021 - mdpi.com
… Many processes are implicated in the pathomechanism of ALS, including neuroinflammation,
RNA processing and metabolism, axonal transport, vesicle trafficking, proteostasis, …

[HTML][HTML] Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy

B Malik, H Devine, R Patani, AR La Spada… - Scientific Reports, 2019 - nature.com
… Our results show CHMP7 protein levels were decreased in the spinal cord of AR100 mice
prior to symptom onset and decreased further following symptom onset. LAMP2 and p62 were …

[HTML][HTML] Buffy coat transcriptomic analysis reveals alterations in host cell protein synthesis and cell cycle in severe COVID-19 patients

LTF Cavalcante, GC da Fonseca… - International Journal of …, 2022 - mdpi.com
analysis revealed 1009 up-regulated and 501 down-regulated genes in the SARS group,
with 10% of both being composed of long non-coding RNA. … enabling traffic of proteins, RNAs, …

[HTML][HTML] Single cell RNA-sequence analyses reveal uniquely expressed genes and heterogeneous immune cell involvement in the rat model of intervertebral disc …

M Rohanifar, SW Clayton, GWD Easson, DS Patil… - Applied Sciences, 2022 - mdpi.com
transcriptionally profiled at the single-cell resolution. Unsupervised cluster analysis revealed
… Differential gene expression analysis revealed multiple distinct cell types from the myeloid …

[HTML][HTML] Single-cell analyses reveal the dynamic functions of Itgb2+ microglia subclusters at different stages of cerebral ischemia-reperfusion injury in transient middle …

F Zeng, J Cao, Z Hong, Y Liu, J Hao, Z Qin… - Frontiers in …, 2023 - frontiersin.org
Frontiers | Single-cell analyses reveal the dynamic functions of Itgb2+ microglia subclusters
at different stages of cerebral ischemia-reperfusion injury in transient middle cerebral …

[HTML][HTML] Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues

D Palmer, F Fabris, A Doherty, AA Freitas… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
analysis and machine learning to functionally describe these signatures, revealing
Further analyses revealed little overlap between genes differentially expressed with age in …

[HTML][HTML] Single-cell RNA sequencing reveals time-and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

S Tansley, S Uttam, A Ureña Guzmán, M Yaqubi… - Nature …, 2022 - nature.com
… and trafficking and has been implicated in AD pathophysiology 30 . Our analyses revealed
that … This analysis revealed associations between transcriptional signatures of distinct mouse …