… As mentioned above, oxaliplatin treatment leads to neuropathic pain and sensitization in
sensory ganglia. It also leads to gap junction changes in the spinal cord, with reactive gliosis …

… Additional evidence for a role for PKC in neuropathic pain comes from a report … the spinal
cord of rats blocks such pain. PKC also has a putative role in enhancing TRPA1-mediated pain. …

… Interestingly, the facilitation of GABAergic currents by diazepam was completely abolished
… When LI–II dorsal horn neurons were examined, facilitation of GABAergic currents by …

… In response to TNF-α, opening of Cx43 hemichannels facilitated the release, but not the
production, … By contrast, the role of spinal astrocytic Cx43 gap junction in neuropathic pain is less …

… and the spinal cord; thus, purinergic signaling in sensory neurons or in spinal circuits may
be critical for pain … These proteins form hemichannels or gap junction channels that mediate …

… might travel via nondiffusible mechanisms, such as gap junctions (56). Thus, this calcium …
This work was facilitated by the Pain Research Core, which is funded by the Blaustein Fund …

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders, which
interferes with daily activities and life of the affected patients. Despite many developments …

… Activated SGC increase Connexin-43 (Cx43) gap junctions … to cause postsynaptic NMDA
facilitation with increased amplitude … spinal cord section of a patient with complex regional pain …

… chronic pain, we compared spread of the gap junction permeant … Together with facilitated
neuron-glial paracrine signaling through … offering a novel target for intervention in chronic pain. …

… , facilitating the … /gap junctions block may be beneficial in cases of spinal cord injury, multiple
connexin inhibitors are currently being investigated for their significant therapeutic potential. …