… review and suggest approaches for AD clinical trial design … overall clinical trial design with
utilized statistical measures that … As the duration, complexity, and cost of clinical trials increase…

… FDA-regulated clinical trial phases as a function of their length, … The following review of
clinical trial data aims at being … of trial design begin with the designation of clinically meaningful …

… and expensive clinical trials, no new drug has been … analyses can reduce the size and
duration of the trial and they may prevent advancing to phase 3 in cases that data show no clinical …

… Aging—Alzheimer's Association Framework on AD represents progress in providing biomarker
profiles of participants in the AD spectrum that can be used to help design clinical trials. …

… of clinical trials used in our evaluation was from ClinicalTrials.… Third, we did not directly
access the failed clinical trial data in … timing of this analysis, we present the most recent AD drug …

… provides an opportunity for clinical trials designed to prevent or … Variable treatment duration
to obtain target number of events. … Furthermore, we will provide a public resource of trial data …

… factors may lower AD clinical trial costs and duration. The use … The present study is not an
exhaustive review of recent ADNI … Data-driven models also predict a role for vascular disease …

… by short follow-up durations, subjective endpoints, small … and quality of data from clinical
trials and/or observational studies. … On the basis of this paper, future clinical trials should focus …

… Aducanumab data included in this meta-analysis were extracted from the presentation
given at “Clinical Trials on AD” conference that took place in December 5, 2019 (EMERGE/…

… We reviewed the underlying mechanisms of these trials, tried to … of a synthetic full-length
Aβ peptide. In 2002, an AN-1792 … Data sharing is not applicable to this article because no …