… PK at steady state for patients with augmented renal clearance (ARC [CL CR of 250 ml/min]).
CI, continuous infusion; … Is prolonged infusion of piperacillin/tazobactam and meropenem in …

… steady state in CSF. In plasma, the median (min–max) total and unbound concentrations after
the loading dose (2 g) administered … During the continuous infusion (6 g/24 h), steady-state …

… , utilization of extended or continuous infusion have been used in … should be taken at
pharmacokinetic steady state, which … burn injury and patient weight (underweight or obese). Some …

… times via prolonged or continuous infusion administration for … However, following patient
exposure, steady-state volumes … Among 15 obese patients intravenously administered 750 mg …

… The use of prolonged infusion could offer advantages for … g) with median reported steady-state
concentrations (Css) level … year-old female patient with a prior history of obesity (weight 90 …

… requires optimisation of the pharmacokinetics and pharmacodynamics for the treatment of
… This review focuses on the pharmacokinetics/pharmacodynamics/toxicodynamics of peptide …

… between antimicrobial dosing, pharmacokinetic/pharmacodynamic (PK/PD) exposure and
… are administered via continuous infusion, a sample at any given time during administration …

… of 2 g IV every 6 h or a continuous infusion of 8–10 g daily … drawn at steady state showed
five of six patients had notable … rates of treatment failure in obese patients, while not increasing …

… , independent of the steady-state plasma concentration of … a 4 h extended infusion, especially
in patients with increased … Recent data also evidence that patients with a BMI ≥30 kg/…

… Steady-state plasma and ELF concentrations of piperacillin … of meropenem administered by
continuous infusion was conducted … intravenous infusion to 22 critically ill obese patients with …