… structural basis for recognition of immune receptors by superantigens, we show that their
binding … cases in the USA are attributed to Staphylococcal enterotoxins (13). In addition, T-cell …

… superantigens, which do not bind to the antigen-binding site of the B cell receptor (BCR), but,
rather, to conserved structures … were designed with reduced or abolished toxicity in mind. …

… findings from this work proves that superantigen properties … Conversely, MHC class II-bound
superantigens achieve TCR … the CDR binding pockets that are more conserved among TCR …

… aureus that bind directly to major histocompatibility complex (… staphylococcal enterotoxin
A (SEA) and staphylococcal … the IFN-γ depletion and isotype antibody groups was abolished, …

… however this process is hampered by the superantigenic binding by SpA, the B cell …
that these changes can completely abrogate the ability of SpA KKAA to bind both the Fc and …

… staphylococcal enterotoxin C (SEC) in complex with the mouse Vβ8.2 chain revealed that
SEC binds to the Vβ chain in a cleft between … , this revealed a structural basis as to how SAgs …

… , superantigens do not bind to CDR3, but instead bind T cells … of PBMCs by staphylococcal
Enterotoxin C1, CD25 + FoxP3 … primary infection results in abrogated memory T cell responses…

… Zn 2+ by EDTA completely abolished MHC class II binding. … a range of different binding
affinities (from nanomolar to … binding of the peptide and of staphylococcal enterotoxin B to …

… may also be facilitated or exacerbated by those non-specific stimuli … when a specific IgE
antibody binding to a broad panel of … a) T cell superantigen: SAgs have superantigen activity and …

… of dHL60 cell lysate by PNGase F abolished SSL11 binding. (18) We hypothesized that the
C-… of the bifunctional staphylococcal enterotoxin-like X (SElX). SEIX, an SSL-like SAg, binds …