… on progranulin (PGRN protein encoded by GRN gene) role in FTLD. Patients with progranulin
… Both progranulin and 6 kDa granulins are shown to exist in vivo, however, their biological …

… Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two decades …

… We have identified progranulin (PGRN) gene as a sex steroid-inducible gene in the brain,
which is involved in masculinization of the brain during the perinatal period and facilitation of …

… Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar
degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual …

… Progranulin (PGRN), a neurotrophic factor expressed mainly in neurons and microglia, has
various neuroprotective effects such as anti-inflammatory effects, promoting neuron survival …

… progranulin expression through a transcriptional mechanism … progranulin through a
posttranscriptional mechanism (Trap1, … boosting progranulin levels by different mechanisms …

… Genetic deficiency from loss-of-function mutations and single-nucleotide polymorphisms
may cause a reduction in progranulin levels. Progranulin deficiency has been implicated in …

… heterozygous loss-of-function mutations in the progranulin gene (GRN) were first … functions
of the progranulin (PGRN) protein, encoded by GRN, multiple possible disease mechanisms …

… of progranulin in microglia, suggesting the existence of a novel sortilin and prosaposin
independent pathway mediating progranulin … trafficking and processing of progranulin in vivo. …

… mechanisms can be highlighted by accumulating evidence for a role for a growth factor,
progranulin … by the GRN/Grn gene with multiple cellular functions, including neurotrophic, anti-…