Copper homeostasis: Emerging target for cancer treatment

Y Li - IUBMB life, 2020 - Wiley Online Library
… Among proteins that require Cu for their function are Cu/Zn superoxide dismutase 1 (SOD1),
cytochrome c oxidase (CCO), ceruloplasmin (CP), lysyl oxidase (LOX), and tyrosinase. Cu-…

Superoxide dismutase as multipotent therapeutic antioxidant enzyme: Role in human diseases

P Saxena, K Selvaraj, SK Khare, N Chaudhary - Biotechnology letters, 2022 - Springer
Superoxide Dismutase is a group of metalloenzymes that are present in every living being
whether be it a plant or animal (Fig. 2). SOD and oxygen share a rare and strong relationship …

[HTML][HTML] Antioxidant therapy in cancer: rationale and progress

M Luo, L Zhou, Z Huang, B Li, EC Nice, J Xu, C Huang - Antioxidants, 2022 - mdpi.com
… In summary, multiple antioxidant therapeutic strategies were developed for cancer treatment,
which can be classified into two different categories of groups according to their targets: …

[HTML][HTML] Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
… The same SOD formulation effectively reduced capsular fibrosis around silicone after
implant surgery in an experimental model resembling breast-cancer treatment in rats [167]. …

Mitochondrial superoxide/hydrogen peroxide: An emerging therapeutic target for metabolic diseases

J Yan, J Jiang, L He, L Chen - Free Radical Biology and Medicine, 2020 - Elsevier
… However, it seems that the production of H 2 O 2 is a consequence of superoxide dismutase
2 (SOD2)-mediated disproportionation [26]. However, the specific electron leak products of …

Utilizing superoxide dismutase mimetics to enhance radiation therapy response while protecting normal tissues

KA Mapuskar, CM Anderson, DR Spitz… - … in radiation oncology, 2019 - Elsevier
treatment with anti-cancer therapies, including chemotherapy 5 and radiation therapy.6, 7
Superoxide dismutase … and utilized small molecule superoxide dismutase mimetics that are …

Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

AC Rosa, N Bruni, G Meineri, D Corsi, N Cavi… - International Journal of …, 2021 - Elsevier
… Endogenous antioxidant enzymes, such as superoxide dismutase (SOD), play an important
role in diminishing oxidative stress. SOD supplementation could therefore be an effective …

Mitochondrial superoxide dismutase: what the established, the intriguing, and the novel reveal about a key cellular redox switch

FR Palma, C He, JM Danes, V Paviani… - Antioxidants & redox …, 2020 - liebertpub.com
… that understanding how the generation of superoxide radicals in mitochondria is coupled …
superoxide dismutase (SOD2) is a major system converting diffusion-restricted superoxide

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

H Zhao, R Zhang, X Yan, K Fan - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Superoxide dismutases (SODs) are a group of metalloenzymes that catalyze the dismutation
of superoxide radicals (O 2 − ) into hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 ). As the …

[HTML][HTML] Redox potential of antioxidants in cancer progression and prevention

S George, H Abrahamse - Antioxidants, 2020 - mdpi.com
… molecules that can regulate cellular redox balance in accordance with the changes in
endogenous ROS production is a solution for many of these challenges in cancer therapy. …