The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy

W Gong, P Liu, T Zheng, X Wu, Y Zhao… - International Reviews of …, 2022 - Taylor & Francis
… -encoding gene Fcer1g while downregulates the expression of … , which ultimately enhances
inflammatory response [Citation49]. This … BAY61-3606 is able to abrogate butyrate-induced …

Novel Inflammatory Mediators in Neuroblastoma Tumorigenesis

C Tümmler - 2019 - munin.uit.no
… of spleen tyrosine kinaseWhile normal fibroblasts can suppress the growth of cancer cells,
CAFs have been coerced by the tumor and can display potent tumor promoting functions [115]…

Effects of Inhibitors against Syk-BTK-PI3K Signaling on Platelet Function

ER Lofurno - 2020 - ir.library.oregonstate.edu
… Our results show that tyrosine kinase inhibitors which target … The Syk inhibitor Bay 61-3606
reduced the number of … While Syk and PI3K inhibitors abrogated platelet spreading on …

The effect of spleen tyrosine kinase inhibitor R406 on diabetic retinopathy in experimental diabetic rats

X Su, ZH Sun, Q Ren, JR Liu, L Yin, N Liang… - International …, 2020 - Springer
… can rapidly activate Syk, whereas Syk inhibitor can ameliorate a … It is worthy to mention that
BAY61-3606, a synthetic Syk inhibitor, … apoptosis and promoting proliferation of retinal cells. …

Mincle as a potential intervention target for the prevention of inflammation and fibrosis

Y Zou, J Li, H Su, N Dechsupa… - Molecular Medicine …, 2024 - spandidos-publications.com
… ITAM then activates splenic tyrosine kinase (Syk) via … promoting repair (38). If the culpable
agent is not eliminated or … Additionally, BAY61-3606 can inhibit Mincle and decrease …

Preventing colorectal cancer through prebiotics

M Mahdavi, I Laforest-Lapointe, E Massé - Microorganisms, 2021 - mdpi.com
While the reasons for this global increase are unclear [6], … on spleen tyrosine kinase (Syk),
a non-receptor tyrosine kinase … provide prebiotic dietary fiber for promoting the growth of L. …

Trichostatin a inhibits phenotypic transition and induces apoptosis of the TAF-treated normal colonic epithelial cells through regulation of TGF-β pathway

C Huang, X Wu, X Wang - The International Journal of Biochemistry & Cell …, 2019 - Elsevier
… EMT through suppression of TGF-β/Smads and promotes the … in the TAF-induced EMT, while
HDAC4 expression was not … promoted the migration of HCoEpiCs at 6 h (1454 ± 126 × 10 …

[HTML][HTML] Autophagy in neuroinflammation: a focus on epigenetic regulation

Y Chen, J Chen, Z Xing, C Peng, D Li - Aging and disease, 2024 - ncbi.nlm.nih.gov
… might suppress the activation of microglia and promoteBAY61-3606, a spleen tyrosine
kinase (SYK) inhibitor, … impairment, while autophagy activation with rapamycin suppressed IL-1β …

The interference between SARS-COV-2 and Alzheimer's disease: Potential immunological and neurobiological crosstalk from a kinase perspective reveals a delayed …

HM Mansour - Ageing Research Reviews, 2024 - Elsevier
tyrosine kinases such as Bruton tyrosine kinase, spleen … alpha (Hif1-α) promotes angiogenesis
by increasing the production of … cells with BAY61-3606 resulted in the suppression of tau …

p38 Molecular Targeting for Next-Generation Multiple Myeloma Therapy

M Morales-Martínez, MI Vega - Cancers, 2024 - mdpi.com
… by blocking proliferation and promoting apoptosis [60,61]. … mentioned, Syk inhibitors,
such as BAY61-3606, R406 or … Spleen tyrosine kinase (Syk) is an intracellular enzyme that …