Background: Despite the widescale success of proton pump inhibitors to reducing the
incidence of peptic ulcer disease, perforated peptic ulcer (PPU) remains a significant cause
of severe complications and death. The implementation of open or surgical repair of PPU
should be guided by reliable guidelines which are based on current systematic evidence.
Objectives: To assess the comparative efficacy and safety of laparoscopic and open repair of
PPU. Methods: A systematic review and meta-analysis was conducted based on …