Pros and cons of clinically relevant methods to assess pain in rodents

A Tappe-Theodor, T King, MM Morgan - Neuroscience & Biobehavioral …, 2019 - Elsevier
… Using appropriate animal models of pain and thoughtful … and neuropathic pain. The second
step in aligning … and train animals to respond, and the potential for surgical pain to confound …

Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
animal models in pharmaceutical drug development, transgenic animal models, models for
… bone and cartilage regeneration model, diabetic and burn wound model as well as surgical

The emergence of animal models of chronic pain and logistical and methodological issues concerning their use

TJ Coderre, A Laferrière - Journal of Neural Transmission, 2020 - Springer
… More recently, animal models of peripheral neuropathic pain … that also produce peripheral
neuropathic pain in humans, further … of animal model and the specific clinical pain (eg surgical

Comparison of different in vivo animal models of brachial plexus avulsion and its application in pain study

H Xian, R Xie, C Luo, R Cong - Neural plasticity, 2020 - Wiley Online Library
… categories according to different surgical approaches, which … neuropathic pain behavior
in ipsilateral and contralateral limbs, and may be a suitable animal model for neuropathic pain

Novel therapies for the treatment of neuropathic pain: potential and pitfalls

P Shinu, MA Morsy, AB Nair, AKA Mouslem… - Journal of Clinical …, 2022 - mdpi.com
… , SCS is used as an effective substitute for local non-surgical … This makes this procedure
surgical, which includes … allodynia and hyperalgesia in neuropathic pain mouse models [130,131…

Animal models of peripheral pain: biology review and application for drug discovery

S Kaliyaperumal, K Wilson, F Aeffner… - Toxicologic …, 2020 - journals.sagepub.com
… commonly utilized neuropathic pain model is the spinal nerve ligation model which involves
… for acute pain in general and postoperative pain are animal models of surgical incision with …

The median nerve injury model in pre-clinical research–a critical review on benefits and limitations

G Ronchi, M Morano, F Fregnan, P Pugliese… - Frontiers in Cellular …, 2019 - frontiersin.org
Surgery on rat peripheral nerves requires less microsurgical skills than needed for mouse
models and rat limbs and nerves are long enough to allow 1.5–2 cm gap repair to be studied …

Advances in assessment of pain behaviors and mechanisms of post-operative pain models

D Segelcke, B Pradier, E Pogatzki-Zahn - Current Opinion in Physiology, 2019 - Elsevier
… sensitization in preclinical models for pain after surgery. We … to some neuropathic pain
models like the spinal nerve ligation … animal models seems to be the detection of relevant pain-…

Neuropathic pain modeling: Focus on synaptic and ion channel mechanisms

R Bouali-Benazzouz, M Landry, A Benazzouz… - Progress in …, 2021 - Elsevier
Animal models of pain consist of modeling a pain-like state and measuring the consequent
behavior. The first animal models of neuropathic pain (… lesion of the sciatic nerve. Later, other …

The importance of animal models in biomedical research: current insights and applications

A Domínguez-Oliva, I Hernández-Ávalos… - Animals, 2023 - mdpi.com
… , pain, rehabilitation medicine, and surgical techniques … temporarily relieve pain by inhibiting
nerve impulse transmission. … , so it is a potential option for treating neuropathic pain [108]. …