Structural aspects of carbohydrate recognition mechanisms of C-type lectins

M Nagae, Y Yamaguchi - C-Type Lectins in Immune Homeostasis, 2020 - Springer
among C-type lectins and C-type lectin-like domains. The … 5 GlcNAc 2 ) from the symmetry
related L-selectin molecule via the … Four complexes in the asymmetric unit are superimposed. f …

C-type lectin-(like) fold–Protein-protein interaction patterns and utilization

J Dohnálek, T Skálová - Biotechnology Advances, 2022 - Elsevier
recognition, interaction surface display, detection of bond types and enhanced display of the
interaction … botrocetin, and one of the asymmetrical interfaces to the heterodimer has higher …

Secondary Sites of the Ctype LectinLike Fold

J Lefèbre, T Falk, Y Ning… - Chemistry–A European …, 2024 - Wiley Online Library
… In a biological context, effective glycan recognition is accomplished by interactions with …
to the interaction with the L1 loop, the stir-up loop, and the β6-strand, creating a 26 symmetric

Fc‐conjugated Ctype lectin receptors: Tools for understanding host–pathogen interactions

JA Willment - Molecular Microbiology, 2022 - Wiley Online Library
… This review will predominantly focus on the recognition of … manner and are termed the C-type
Lectin-like domains (CTLD) an … binding brings two symmetrical trimeric molecules together. …

Novel carbohydrate-recognition mode of the invertebrate C-type lectin SPL-1 from Saxidomus purpuratus revealed by the GlcNAc-complex crystal in the presence of …

H Unno, S Higuchi, S Goda… - … Section F: Structural …, 2020 - journals.iucr.org
… The detailed interactions between SPL-1 and GlcNAc are shown in … from multiple observations
of symmetryrelated reflections. … C-type CRDs, or more comprehensively C-type lectin-like

Novel Ca2+‐independent carbohydrate recognition of the Ctype lectins, SPL‐1 and SPL‐2, from the bivalve Saxidomus purpuratus

H Unno, S Itakura, S Higuchi, S Goda… - Protein …, 2019 - Wiley Online Library
… stacking interactions between its … asymmetric unit included only one polypeptide of B-chain
that was disulfide bonded with the next protomer related by crystallographic twofold symmetry

[HTML][HTML] Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells

S Barbera, L Raucci, G Tassone, L Tinti… - International Journal of …, 2023 - Elsevier
… antibody 4E1, which recognizes a conformational epitope on … Crystallographic analysis
showed that the crystal asymmetric … D1X-pr dimer is generated by binary symmetry (Fig. 5B; the …

[HTML][HTML] Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls

I Vendele, JA Willment, LM Silva, AS Palma… - PLoS …, 2020 - journals.plos.org
… Understanding the relationship between fungal cell wall composition and immune … Median
fluorescence intensity for asymmetric peaks and mean fluorescence intensity for symmetric

Lectin antagonists in infection, immunity, and inflammation

J Meiers, E Siebs, E Zahorska, A Titz - Current Opinion in Chemical Biology, 2019 - Elsevier
… the fact that usually low affinity interactions between lectin and … one catalytic A-subunit and
five lectin-like B-subunits (Figure 1… GlcNAc is recognized by both C-type lectins but sulfation of …

The unique 3D arrangement of macrophage galactose lectin enables Escherichia coli lipopolysaccharide recognition through two distinct interfaces

M Abbas, M Maalej, F Nieto-Fabregat, M Thépaut… - PNAS …, 2023 - academic.oup.com
… , they are recognized by immunity C-type lectin receptors … is compositionally asymmetric with
lipopolysaccharides (LPSs) … , doing five runs including P3 symmetry and prolate anisotropy. …