Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity
… Together, these results indicate that IL-7–CBD and CBD–IL-12 display a significant synergy
… , corroborating the synergistic effect between IL-7–CBD and CBD–IL-12. Upon further …
… , corroborating the synergistic effect between IL-7–CBD and CBD–IL-12. Upon further …
IL-7 coupled with IL-12 increases intratumoral T cell clonality, leading to complete regression of non-immunogenic tumors
M Tasaki, M Yamashita, Y Arai, T Nakamura… - Cancer Immunology …, 2021 - Springer
… of IL-7 together with IL-12 increased a limited number of T cell … between IL-12 alone and
the combination of IL-7 and IL-12. … IL-7 has been reported to synergistically stimulate T cells in …
the combination of IL-7 and IL-12. … IL-7 has been reported to synergistically stimulate T cells in …
Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade
…, M Yamashita, R Murakami, T Kawase… - Science translational …, 2020 - science.org
… of CD8 + cytotoxic T cells and CD45RO + memory T cells into tumors (… IL-7 and IL-12 induced
by hIL-7/mIL-12-VV synergistically activated and expanded T cells, NK cells, and NKT cells …
by hIL-7/mIL-12-VV synergistically activated and expanded T cells, NK cells, and NKT cells …
Toll‐like receptor‐2/7‐mediated T cell activation: An innate potential to augment CD8+ T cell cytokine production
JJ Freen‐van Heeren - Scandinavian journal of immunology, 2021 - Wiley Online Library
… IL-7 + TLR2 ligands and IL-12 + TLR2 or TLR7 ligands … combined IL-12 and TLR2/7
ligand-mediated T cell stimulation, … therapy, indicating a synergistic action between the TLR …
ligand-mediated T cell stimulation, … therapy, indicating a synergistic action between the TLR …
IL-12 expands and differentiates human Vγ2Vδ2 T effector cells producing antimicrobial cytokines and inhibiting intracellular mycobacterial growth
… On the other hand, activated Vγ2Vδ2 T cells can be expanded by IL-2, IL-7, IL-15, IL-21,
IL-33, and Th17-related cytokines (13, 18–21). Furthermore, recent seminal studies in NHP …
IL-33, and Th17-related cytokines (13, 18–21). Furthermore, recent seminal studies in NHP …
Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors
F Li, S Zhao, C Wei, Y Hu, T Xu, X Xin, T Zhu… - Frontiers in …, 2022 - frontiersin.org
… had potential therapeutic efficacy and exerted a synergistic role with FAP-12 CAR-T cells,
further … therapy showed synergistic effects in the mouse model of lung metastasis …
further … therapy showed synergistic effects in the mouse model of lung metastasis …
[HTML][HTML] Harnessing the power of IL-7 to boost T cell immunity in experimental and clinical immunotherapies
JH Park, SW Lee, D Choi, C Lee, YC Sung - Immune Network, 2024 - ncbi.nlm.nih.gov
… zone of lymph nodes act synergistically in CAR-T cell therapy. The 7×19 CAR-… 7 has a
relatively good safety profile compared to IL-2 and IL-12 administration (46,67), there could be still …
relatively good safety profile compared to IL-2 and IL-12 administration (46,67), there could be still …
[HTML][HTML] Enhanced human T lymphocyte antigen priming by cytokine-matured dendritic cells overexpressing bcl-2 and IL-12
H Zhang, Y Wang, QT Wang, SN Sun, SY Li… - Frontiers in Cell and …, 2020 - frontiersin.org
… IL-7 were supplied every 3 days. On day 14, non-adherent cells were harvested and used as
effector T cells, … expression synergistically promote the ability of human DCs to prime CD8 + …
effector T cells, … expression synergistically promote the ability of human DCs to prime CD8 + …
Brief in vitro IL-12 conditioning of CD8 + T Cells for anticancer adoptive T cell therapy
ML Salem, S Salman, IO Barnawi - Cancer Immunology, Immunotherapy, 2021 - Springer
… such as IL-7, IL-12, IL-15, and IL-22 to program T cells ex vivo with the main goal to enhance
the proliferation, activation, survival, and effector function of the transferred T cells [52, 53]. …
the proliferation, activation, survival, and effector function of the transferred T cells [52, 53]. …
Interleukin (IL)-12 and IL-18 synergize to promote MAIT cell IL-17A and IL-17F production independently of IL-23 signaling
S Cole, J Murray, C Simpson, R Okoye… - Frontiers in …, 2020 - frontiersin.org
… synergistic combination of IL-12 and IL-18 (Figures 2B–D). … by ILC3s upon stimulation with
IL-1β, IL-2 and IL-7, with or … and γδ T cells required IL-12, ILC3s did not require IL-12 or IL-…
IL-1β, IL-2 and IL-7, with or … and γδ T cells required IL-12, ILC3s did not require IL-12 or IL-…