IL‐15 and IL‐23 synergize to trigger Th17 response by CLA+ T cells in psoriasis
C de Jesús‐Gil, E Ruiz‐Romeu… - Experimental …, 2020 - Wiley Online Library
… with IL-2 and IL-7 in regulating T-cell turnover. However, IL-… families, such as IL-2 and IL-12,
corresponding to the IL-15 and … synergic action of IL-15 and IL-23 induced greater activation …
corresponding to the IL-15 and … synergic action of IL-15 and IL-23 induced greater activation …
Significance of IL-7 and IL-7R in RA and autoimmunity
A Meyer, PJ Parmar, S Shahrara - Autoimmunity reviews, 2022 - Elsevier
… contrary, circulating IL-7 is closely connected to T-bet … , IL-7 potentiated TNF secretion from
RA SFMCs and expanded IFNγ production from RA SF CD4+ T cells in part through an IL-12 …
RA SFMCs and expanded IFNγ production from RA SF CD4+ T cells in part through an IL-12 …
[HTML][HTML] … on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7× CCL19 results in …
H Hu, S Zhang, L Cai, H Duan, Y Li, J Yang, Y Wang… - Virology Journal, 2022 - Springer
… And they demonstrated that IL-7 and IL-12 combination virotherapy could increase the … +
T cells clonality and anti-tumor response rate as well [29]. The synergistic effect of IL-12 and IL-…
T cells clonality and anti-tumor response rate as well [29]. The synergistic effect of IL-12 and IL-…
[HTML][HTML] Harnessing the power of IL-7 to boost T cell immunity in experimental and clinical immunotherapies
JH Park, SW Lee, D Choi, C Lee, YC Sung - Immune Network, 2024 - ncbi.nlm.nih.gov
… zone of lymph nodes act synergistically in CAR-T cell therapy. The 7×19 CAR-… 7 has a
relatively good safety profile compared to IL-2 and IL-12 administration (46,67), there could be still …
relatively good safety profile compared to IL-2 and IL-12 administration (46,67), there could be still …
[HTML][HTML] IL-7 During Antigenic Stimulation Using Allogeneic Dendritic Cells Promotes Expansion of CD45RA-CD62L+CD4+ Invariant NKT Cells With Th-2 Biased …
A Trujillo-Ocampo, HW Cho, M Clowers… - Frontiers in …, 2020 - frontiersin.org
… This synergistic increase was not present with the addition of … presence of IL-12 can drive
activated iNKT cells to increase … killer T cells in the early human fetal thymus is regulated by IL-7…
activated iNKT cells to increase … killer T cells in the early human fetal thymus is regulated by IL-7…
[HTML][HTML] Combined in vitro IL-12 and IL-15 stimulation promotes cellular immune response in dogs with visceral leishmaniasis
SF Costa, VO Gomes… - PLoS Neglected …, 2020 - journals.plos.org
… studies evaluating the activities of IL-7 in humans or dogs with … showing additive or
synergistic effects have already been … leishmaniasis occurs due to T lymphocyte exhaustion [45], …
synergistic effects have already been … leishmaniasis occurs due to T lymphocyte exhaustion [45], …
[HTML][HTML] Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine
… T cells via granzyme B secretion leading to tumor cell death. IL-12 promotes Th1 differentiation
in CD4 + T cells… , induces synergistic antitumor effects including immune stimulation and …
in CD4 + T cells… , induces synergistic antitumor effects including immune stimulation and …
[HTML][HTML] Interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis
D Chen, TX Tang, H Deng, XP Yang… - Frontiers in …, 2021 - frontiersin.org
… IL-7 was induced in the presence of IL-12, the diversity of intratumoral CD8+ T cells increased,
and IL-12 … reduced, indicating a synergistic effect from IL-7 in maintaining ILC1s (66). …
and IL-12 … reduced, indicating a synergistic effect from IL-7 in maintaining ILC1s (66). …
IL-12 conditioning of peripheral blood mononuclear cells from breast cancer patients promotes the zoledronate-induced expansion of γδ T cells in vitro and enhances …
… IL-2, IL- 7, IL-15, IL-21… IL-12 to optimize the expansion and function of γδ T cells induced by
ZOL and IL-2. To address this aim, we added IL-12 with both ZOL and IL-2 on day 0 of the cell …
ZOL and IL-2. To address this aim, we added IL-12 with both ZOL and IL-2 on day 0 of the cell …
[HTML][HTML] Immunology of IL-12: An update on functional activities and implications for disease
KAM Ullrich, LL Schulze, EM Paap, TM Müller… - EXCLI …, 2020 - ncbi.nlm.nih.gov
… effect on resting peripheral T cells or NK cells, IL-12 directly … Eg, for T cells and NK cells,
IL-12 acts synergistically with IL-2 … IFN-γ, in synergy with IL-12, it induces gene transcription via …
IL-12 acts synergistically with IL-2 … IFN-γ, in synergy with IL-12, it induces gene transcription via …