… substrates in the synthesis of several biologically active heterocyclic compounds and drug
intermediates, were chosen in this study for the synthesis of pyrazolo[1,5-a]pyrimidines 11a–j. …

… pyrazolo[1,5-a]pyrimidine ring system constitutes a privileged scaffold for developing drug-like
compounds, whose biologic activity … synthesis of nine 2,7-diarylpyrazolo[1,5-a]pyrimidine …

… anti-tumor activities [18], [19], [20], [21], [22], [23], [24]. Furthermore, as a pharmacophore, the
similar structural features between the pyrazolo[1,5-a]pyrimidine … as pyridine and pyrimidine…

… In this work, novel oxazolo[5,4-d]pyrimidine derivatives were designed, synthesized, and
evaluated in vitro for their cytotoxic activity against a panel of four human cancer cell lines (lung …

… for the discovery of novel antitumor agents 12,13. Pyrazolo[1,5-a]pyrimidines (PP) are a …
In this research, we have developed new derivatives having the pyrazolo[1,5-a]pyrimidine …

… activity of pyrazolo[1,5-a]pyrimidines [24, 25] and pyrazolo[3,4-b]pyridines [26, 27], we aimed
herein, to synthesize … antitumor activity when compared with cisplatin (Table 2). From IC50 …

… anti-tumor activity of the prepared compounds (listed in Table 1 ) against different tumor cell
lines (listed in Table 1 ). … The present study describes the synthesis and antitumor activity of a …

… ring fused to pyrimidine, pyridine and imidazole rings are of … 1 Pyrazolopyrimidines
exhibited various biological activities … have devised an efficient synthesis for pyrazolo[3,4-d]pyridine-6(…

… to prepare different pyrazolo[1,5-a]pyrimidine derivatives (12–20… synthesis and investigates
the anti-inflammatory activities of some new polyfunctionalized pyrazole, pyrimidine, pyrazolo…

… pyrazolo[3,4-d] pyrimidine derivatives have been proven to have significant anti-tumor activity.
… -Tobacco mosaic virus activity, but compounds containing a pyridine ring (compound 26g) …