… In this research, seven chalcone-based compounds were synthesized, and their efficacy
was evaluated in the hot-plate (supraspinal) and tail-immersion (spinal) tests, standard for …

… Purpose: Chalcones are precursors of flavonoids with a wide … the anti-inflammatory effect of
indole based chalcone … model were employed to evaluate the anti-inflammatory activity of IC9…

… derivatives ranks 9th among the top 25 FDA approved drugs with 17 indole containing drugs
in the market [37]. There are two active indole-based lead candidates, NITD-304 and NITD-…

… in this work possess potential for the development of innovative chemotherapeutic agents. …
Here, we evaluated indole-based chalcones in terms of antimicrobial and anti-TB effects. …

… In a constant effort to identify potential … synthesized indole-hybrid chalcones in our laboratory
[6,7,22]. Continuing this research, new indole chalcones were designed, synthesized, and …

… Indole-based chalcones have huge biological importance like … , chalcone and 1,2,3-triazole
units into a single molecule. We report herein the synthesis of a new series indole-chalcone-1…

… Additionally, indole-based indomethacin V is a potent NSAID used for the treatment of
inflammatory diseases such as rheumatoid arthritis and osteoarthritis [20]. Still, due to its high …

… indole-based anti-inflammatory agents and also for drugs that are selective inhibitors of
COX-2 over COX-1 for enhanced anti-inflammatory … to afford chalcones 153 which were further …

… Thus, we aim to join these fragments to build new molecules of anti-inflammatory interest. …
the anti-inflammatory potential of new indole-thiosemicarbazone derivatives. After synthesis …

… of therapeutic agents [8-10]. In the last decade, many researchers have reported different
indole-based compounds with discrete mechanisms involved in producing potential anticancer …