… Cryptococcus neoformans is an environmental basidiomycete fungus and opportunistic human
pathogen. It causes Cryptococcosis … advanced cases of Cryptococcal infections are often …

… under oxygen action and polymerize into melanin. The size of … , as melanin synthesis by
Cryptococcus neoformans actually … Moreover, different strains of mice that differed only in the …

… Cryptococcus neoformans produces pigments from many … confirmed that l-DOPA had
polymerized to form melanin. … may be associated with melanin synthesis and externalization. …

… The DHN is polymerized to form DHN-melanin with the … important for the synthesis of
DHN-melanin, DOPA-melanin, and … using mice, the radioprotective effect of extracellular melanin …

… older cells during infection in rats and in humans95,107. … Melanin synthesis occurs in the cell
wall through the … into quinones which then polymerize into pigmented melanin products150. …

… in animal models of infection; and acid digestion of infected rodent tissue revealed melanin
“… that can be used as substrates for melanin synthesis, and the permissiveness of the low-…

… is a macromolecular substance formed by polymerizing … -pathogenic fungi such as
Cryptococcus neoformans (24, 25) … is compartmentalization of the melanin synthesis enzymes. …

… neoformans also possesses laccases (CNLAC1 and … which further get polymerized into
melanin pigment and confer … ) mediates the synthesis of melanin pigment which contributes to …

… The functional versatility of melanin within biological systems … dictated by melanin synthesis
and polymerization conditions … of Cryptococcus neoformans to ionizing radiation found that …

… very limited knowledge on the overall capsule synthesis, and structure (Drouhet and Segretain,
… to be slightly higher for IN infected mice. In the IV-infected mice we may also observe an …