[HTML][HTML] Synthesis of 2, 7-diarylpyrazolo [1, 5-a] pyrimidine derivatives with antitumor activity. Theoretical identification of targets

A Ballesteros-Casallas, M Paulino, P Vidossich… - European Journal of …, 2022 - Elsevier
… Similar explorative analysis performed on other putative targets identified by the RVS
suggests the design of new pyrazolo[1,5-a]pyrimidine derivatives with higher calculated affinities …

Three‐component synthesis of arene‐linked pyrazolo[1,5‐a]pyrimidines

AAM Ahmed, AEM Mekky… - Journal of Heterocyclic …, 2023 - Wiley Online Library
… method for synthesizing two new series of arene-linked pyrazolo[1,5-a]pyrimidines. This was
… established to synthesize two new series of arene-linked pyrazolo[1,5-a]pyrimidines. The …

Three-component regioselective synthesis and antibacterial evaluation of new arene-linked bis(pyrazolo[1,5-a]pyrimidine) hybrids

SMH Sanad, AEM Mekky - Synthetic Communications, 2023 - Taylor & Francis
synthesize butane-linked bis(pyrazolo[1,5-a]pyrimidines) 1 … series of regioisomeric bis(pyrazolo[1,5-a]pyrimidines)
2 was … The new products showed a wide spectrum of antibacterial …

Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia

SJ Almehmadi, AMR Alsaedi, MF Harras… - Bioorganic …, 2021 - Elsevier
… In this study, new CDK2 inhibitors bearing the pyrazolo[1,5-a]pyrimidine core were developed.
All the target compounds were characterized for their anti-CDK2 action with excellent to …

Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo [1, 5-a] pyrimidine derivatives as potential c-Met inhibitors

G Luo, Y Ma, X Liang, G Xie, Y Luo, D Zha, S Wang… - Bioorganic …, 2020 - Elsevier
… With the aim of exploring new pyrazolo[1,5-a]pyrimidine-based type II c-Met inhibitors, the
… Specifically, pyrazolo[1,5-a]pyrimidine fragments were introduced into block D and different …

SYNTHESIS OF PYRAZOLO [1, 5-a][1, 3, 5] TRIAZINE AND OXAZOLO [4, 5-d] PYRIMIDINE DERIVATIVES AND STUDY OF THEIR VASODILATOR ACTIVITY.

YS Velihina, SG Pilyo, IV Ivanova… - Issues of Chemistry & …, 2023 - search.ebscohost.com
… Oxazolo [4, 5-d] pyrimidines with a labile chlorine atom in … oxazolo [4, 5-d] pyrimidine, were
obtained by heating the latter … synthesized compounds on vascular tone showed that some of …

In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …

AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
… , our work synthesized twelve 5-aryl-pyrazolo[1,5-a]pyrimidine … reported 7-aryl-pyrazolo[1,5-a]pyrimidine
derivatives 5a–f to … synthesized and classified as twelve 5-aryl-pyrazolo[1,5-a]…

One-pot three-component synthesis of novel pyrano [3, 2-e] pyrazolo [1, 5-a] pyrimidines and investigation of their biological activities

MM Vahedi, S Asghari, M Tajbakhsh, M Mohseni… - Journal of Molecular …, 2023 - Elsevier
… In this study, pyrano[3,2-e]pyrazaolo[1,5-a]pyrimidine derivatives were produced in high … ,
and 7‑hydroxy pyrazolo[1,5-a]pyrimidines. Using FT-IR, 1 H and 13 C NMR, and mass spectral …

[HTML][HTML] A New Method for the Synthesis of 3-Thiocyanatopyrazolo[1,5-a]pyrimidines

VA Kokorekin, SV Neverov, VN Kuzina, VA Petrosyan - Molecules, 2020 - mdpi.com
several approaches to the efficient C–H (An) thiocyanation of substituted pyrazolo[1,5-a]pyrimidines
Such structures are of big interest, because pyrazolo[1,5-a]pyrimidine is one of the …

[HTML][HTML] Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero) arylidene, pyrazolo [1, 5-a] pyrimidine and triazolo [1, 5-a] pyrimidine moieties …

MA Kiss, M Peřina, V Bazgier, NV May, Á Baji… - The Journal of Steroid …, 2021 - Elsevier
… derivative 2a, in order to find the optimum conditions for the synthesis of pyrazolo[1,5-a]pyrimidines
and triazolo[1,5-a]pyrimidines (Scheme 1). Although t-BuOK has often been used as …