[HTML][HTML] Synthesis of 2, 7-diarylpyrazolo [1, 5-a] pyrimidine derivatives with antitumor activity. Theoretical identification of targets
A Ballesteros-Casallas, M Paulino, P Vidossich… - European Journal of …, 2022 - Elsevier
… Similar explorative analysis performed on other putative targets identified by the RVS
suggests the design of new pyrazolo[1,5-a]pyrimidine derivatives with higher calculated affinities …
suggests the design of new pyrazolo[1,5-a]pyrimidine derivatives with higher calculated affinities …
Three‐component synthesis of arene‐linked pyrazolo[1,5‐a]pyrimidines
… method for synthesizing two new series of arene-linked pyrazolo[1,5-a]pyrimidines. This was
… established to synthesize two new series of arene-linked pyrazolo[1,5-a]pyrimidines. The …
… established to synthesize two new series of arene-linked pyrazolo[1,5-a]pyrimidines. The …
Three-component regioselective synthesis and antibacterial evaluation of new arene-linked bis(pyrazolo[1,5-a]pyrimidine) hybrids
… synthesize butane-linked bis(pyrazolo[1,5-a]pyrimidines) 1 … series of regioisomeric bis(pyrazolo[1,5-a]pyrimidines)
2 was … The new products showed a wide spectrum of antibacterial …
2 was … The new products showed a wide spectrum of antibacterial …
Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia
… In this study, new CDK2 inhibitors bearing the pyrazolo[1,5-a]pyrimidine core were developed.
All the target compounds were characterized for their anti-CDK2 action with excellent to …
All the target compounds were characterized for their anti-CDK2 action with excellent to …
Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo [1, 5-a] pyrimidine derivatives as potential c-Met inhibitors
G Luo, Y Ma, X Liang, G Xie, Y Luo, D Zha, S Wang… - Bioorganic …, 2020 - Elsevier
… With the aim of exploring new pyrazolo[1,5-a]pyrimidine-based type II c-Met inhibitors, the
… Specifically, pyrazolo[1,5-a]pyrimidine fragments were introduced into block D and different …
… Specifically, pyrazolo[1,5-a]pyrimidine fragments were introduced into block D and different …
SYNTHESIS OF PYRAZOLO [1, 5-a][1, 3, 5] TRIAZINE AND OXAZOLO [4, 5-d] PYRIMIDINE DERIVATIVES AND STUDY OF THEIR VASODILATOR ACTIVITY.
YS Velihina, SG Pilyo, IV Ivanova… - Issues of Chemistry & …, 2023 - search.ebscohost.com
… Oxazolo [4, 5-d] pyrimidines with a labile chlorine atom in … oxazolo [4, 5-d] pyrimidine, were
obtained by heating the latter … synthesized compounds on vascular tone showed that some of …
obtained by heating the latter … synthesized compounds on vascular tone showed that some of …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
… , our work synthesized twelve 5-aryl-pyrazolo[1,5-a]pyrimidine … reported 7-aryl-pyrazolo[1,5-a]pyrimidine
derivatives 5a–f to … synthesized and classified as twelve 5-aryl-pyrazolo[1,5-a]…
derivatives 5a–f to … synthesized and classified as twelve 5-aryl-pyrazolo[1,5-a]…
One-pot three-component synthesis of novel pyrano [3, 2-e] pyrazolo [1, 5-a] pyrimidines and investigation of their biological activities
… In this study, pyrano[3,2-e]pyrazaolo[1,5-a]pyrimidine derivatives were produced in high … ,
and 7‑hydroxy pyrazolo[1,5-a]pyrimidines. Using FT-IR, 1 H and 13 C NMR, and mass spectral …
and 7‑hydroxy pyrazolo[1,5-a]pyrimidines. Using FT-IR, 1 H and 13 C NMR, and mass spectral …
[HTML][HTML] A New Method for the Synthesis of 3-Thiocyanatopyrazolo[1,5-a]pyrimidines
VA Kokorekin, SV Neverov, VN Kuzina, VA Petrosyan - Molecules, 2020 - mdpi.com
… several approaches to the efficient C–H (An) thiocyanation of substituted pyrazolo[1,5-a]pyrimidines …
Such structures are of big interest, because pyrazolo[1,5-a]pyrimidine is one of the …
Such structures are of big interest, because pyrazolo[1,5-a]pyrimidine is one of the …
[HTML][HTML] Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero) arylidene, pyrazolo [1, 5-a] pyrimidine and triazolo [1, 5-a] pyrimidine moieties …
… derivative 2a, in order to find the optimum conditions for the synthesis of pyrazolo[1,5-a]pyrimidines
and triazolo[1,5-a]pyrimidines (Scheme 1). Although t-BuOK has often been used as …
and triazolo[1,5-a]pyrimidines (Scheme 1). Although t-BuOK has often been used as …