[HTML][HTML] Construction of lymph nodes-targeting tumor vaccines by using the principle of DNA base complementary pairing to enhance anti-tumor cellular immune …

Y Zha, L Fu, Z Liu, J Lin… - Journal of …, 2024 - jnanobiotechnology.biomedcentral …
… unique capability to initiate precise anti-tumor immune responses and establish enduring …
-pairing-triggered aggregation, we demonstrate the occurrence of nanoparticle aggregation …

Emerging advances in synthetic cancer nano-vaccines: opportunities and challenges

MZ Ahmad, J Ahmad, A Haque… - … review of vaccines, 2020 - Taylor & Francis
Nanoparticles (NPs) vaccine delivery … a better target to an effective immune response.
They can be quickly drained via lymphatic systems to lymph nodes, which is full of immune cells. …

In Situ Programming of Nanovaccines for Lymph Node-Targeted Delivery and Cancer Immunotherapy

L Jin, D Yang, Y Song, D Li, W Xu, Y Zhu, CF Xu, Y Lu… - ACS …, 2022 - ACS Publications
… a series of events activating the host’s own immune system. (… the migration of the
nanoparticles into LNs and their … to enhance the antitumor immunity of in situ cancer vaccines. …

Harnessing innate immunity using biomaterials for cancer immunotherapy

DY Lee, K Huntoon, Y Wang, W Jiang… - Advanced …, 2021 - Wiley Online Library
antitumor immunity will likely require engaging both the … NPs specifically targeted lymph node
with negligible targeting to … [ 72 ] When combined with nanotechnology, the adverse events …

[HTML][HTML] Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy

J Zhuang, M Holay, JH Park, RH Fang, J Zhang… - Theranostics, 2019 - ncbi.nlm.nih.gov
… promising means of elevating antitumor immunity. Here, we … of nanoparticles, thus enhancing
uptake efficiency by target … help to enhance nanoparticle localization in the lymph nodes, …

A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion

SM Jin, YJ Yoo, HS Shin, S Kim, SN Lee… - … Nanotechnology, 2023 - nature.com
… Here we suggest a kinetically activating nanoadjuvant (K-… to and retention in the lymph nodes
(LNs) after subcutaneous … the off-target site and recovery (active) at the target site’ strategy …

Mannan-decorated pathogen-like polymeric nanoparticles as nanovaccine carriers for eliciting superior anticancer immunity

Y Xu, S Ma, J Zhao, H Chen, X Si, Z Huang, Z Yu… - Biomaterials, 2022 - Elsevier
… synergize with CpG for maximally activating the DCs. Excitingly… role in the lymph node drainage
of nanoparticles, with sizes … Besides, decorating particles with actively targeting moieties, …

Co-delivery of antigen and dual adjuvants by aluminum hydroxide nanoparticles for enhanced immune responses

Y Hou, Y Wang, Y Tang, Z Zhou, L Tan, T Gong… - Journal of controlled …, 2020 - Elsevier
… hydroxide that would allow lymph node targeting, we used a PEG-… protective antitumor
immunity as a prophylactic vaccine. … viral pathogens for triggering innate immune responses [36]. …

Surface-engineered cubosomes serve as a novel vaccine adjuvant to modulate innate immunity and improve adaptive immunity in vivo

Z Liu, L Yu, P Gu, R Bo, S Xu, A Wusiman… - International Journal …, 2020 - Taylor & Francis
… -GLPC nanoparticles would function as an effective adjuvant and vaccine system to target
… activity in terms of activating DCs in the draining lymph nodes. The activation markers (CD80…

Vaccine delivery systems toward lymph nodes

Y Ding, Z Li, A Jaklenec, Q Hu - Advanced Drug Delivery Reviews, 2021 - Elsevier
… efficient lymph node targeting and improve vaccine-triggeredanti-tumor immune responses
in the lymph nodes, the … , and the authors screened the nanoparticle structure to optimize the …