Functional nanomaterials optimized to circumvent tumor immunological tolerance
… through lymph nodes than larger ones (100 nm), and nanoparticles ranging … enhance the
antitumor immune response.174 Nanomaterials can specifically deliver their cargo to targeted …
antitumor immune response.174 Nanomaterials can specifically deliver their cargo to targeted …
Nanovaccines for cancer immunotherapy
… vaccines to target lymphoid tissues and cells, thereby promoting the potency and durability
of anti-tumor immunity … subunit vaccines, resulting in efficient accumulation in lymph nodes …
of anti-tumor immunity … subunit vaccines, resulting in efficient accumulation in lymph nodes …
Vaccine-like nanomedicine for cancer immunotherapy
Y Yi, M Yu, W Li, D Zhu, L Mei, M Ou - Journal of Controlled Release, 2023 - Elsevier
… with targeting units further permits the delivery of vaccines to … available to stimulate strong
antitumor immune responses [24]. … and migration ability toward lymph nodes of DCs, leading to …
antitumor immune responses [24]. … and migration ability toward lymph nodes of DCs, leading to …
PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination
X Liu, Q Su, H Song, X Shi, Y Zhang, C Zhang… - Biomaterials, 2021 - Elsevier
… that do not express antigens targeted by vaccination-induced … The employment of
antigen-capturing nanoparticles [24,25], … be effective vehicles for vaccine delivery to lymph nodes …
antigen-capturing nanoparticles [24,25], … be effective vehicles for vaccine delivery to lymph nodes …
[HTML][HTML] Activation of Cellular Players in Adaptive Immunity via Exogenous Delivery of Tumor Cell Lysates
J Seong, K Kim - Pharmaceutics, 2022 - mdpi.com
… Enhanced antitumor immunity and cancer vaccination … of calcium pyrophosphate nanoparticles
coated with antigen-rich … mDCs activation, improved lymph node targeting, and facilitated …
coated with antigen-rich … mDCs activation, improved lymph node targeting, and facilitated …
[HTML][HTML] Nanomaterials in tumor immunotherapy: new strategies and challenges
X Zhu, S Li - Molecular Cancer, 2023 - Springer
… There are two main classes of novel nanoparticles … the targeting ability of tumor, restore the
anti-tumor immune … size of primary tumor while activating anti-tumor immunity. Results from in …
anti-tumor immune … size of primary tumor while activating anti-tumor immunity. Results from in …
In situ vaccination with nanoparticles for cancer immunotherapy: understanding the immunology
C Mao, MJ Gorbet, A Singh, A Ranjan… - International Journal of …, 2020 - Taylor & Francis
… on using nanotechnology to stimulate antitumor immunity to … express goal of generating local
and systemic antitumor immune … in the draining lymph nodes. Consequently, matured DCs …
and systemic antitumor immune … in the draining lymph nodes. Consequently, matured DCs …
Improving cancer vaccine efficiency by nanomedicine
J Cai, H Wang, D Wang, Y Li - Advanced biosystems, 2019 - Wiley Online Library
… effect, presumably due to the limited lymph nodes (LNs) … do enhance crosspresentation
and evoke antitumor immune … -antibody immune complexes) mimicking synthetic vaccine NPs …
and evoke antitumor immune … -antibody immune complexes) mimicking synthetic vaccine NPs …
[HTML][HTML] Nano drug delivery system for tumor immunotherapy: next-generation therapeutics
L Zhou, M Zou, Y Xu, P Lin, C Lei, X Xia - Frontiers in oncology, 2022 - frontiersin.org
… nanotechnology to achieve active and passive dual targeting… antigens to lymph nodes and
trigger humoral immunity as well … found to significantly enhance anti-tumor immune response, …
trigger humoral immunity as well … found to significantly enhance anti-tumor immune response, …
Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response
… synthetic lipid used in the COVID-19 vaccine Comirnaty. The … antitumor immunity generated
by our mRNA cancer vaccine. … vaccine reduces the population of Treg cells by activating the …
by our mRNA cancer vaccine. … vaccine reduces the population of Treg cells by activating the …