… A key challenge is the diversity of cellular processes that are regulated by TBK1, including
… , as in prostate cancer TBK1 can promote cancer dormancy by mTORC1 inhibition [Citation…

… We thus further investigated whether TBK1 regulates GLUT1 by suppressing mTORC1 …
that the pharmacological inhibition of TBK1 could also induce inhibition of cell proliferation and …

… Studies suggest that TBK1 inhibition suppresses cancer development not only by … using
patient samples. We discuss the molecular mechanisms by which TBK1 is regulated in cancer …

… However, whether TBK1 promotes or inhibits mTOR activity is … TBK1 regulates mTOR, we
tested the hypothesis that TBK1 … of mTOR was linked to prostate cancer dormancy 6 . In a …

… expression of TANK binding kinase 1 (TBK1), which induces dormancy (Ki67-negative cells)
[… We demonstrate that ABA inhibits PCa cell proliferation and significantly increased G 0 cell …

… We also highlight the role of the mTOR pathway in regulating autophagy, in addition … TBK1),
by interacting with mTOR and inhibiting its function, stimulates prostate cancer cell dormancy …

… Lipopolysaccharide (LPS) treatment induces TBK1/IKKi-… that TBK1 regulates PCa dormancy
and chemotherapeutic resistance in PC3 and C4-2B models. TBK1 can interact with mTOR …

… to prostate cancer dormancy through activation of p38 (74). … 7) regulated dormancy of
prostate cancer cells through … During DIRAS3-induced dormancy, mTOR inhibition promoted …

… TBK1 is controlled via adaptor proteins that regulate its … the TBK1-mediated tumor
microenvironment and cancer development. … promising inhibitors of TBK1 implicated in cancer …

… It has been shown that TBK1 can influence the autophagy flux by directly regulating
mTOR … Whether TBK1 promotes or inhibits mTOR activity is highly cell-type- and context-dependent…