… MAPK pathway activity, by recruiting SHP-1 or SHP-2 at the TCR … to it are agonists or competing
with endogenous ligands [77]. … a mutated SHP-1 gene featured enhanced TCR signaling …

… the components of these pathways have been proposed to … phosphatase and positive
feedback mediated by the Erk kinase. … but imperfect discrimination produced by the TCR and is …

… In fact, SHP-1 was reported to be recruited to the TCR upon … pathways might be an issue
when considering SHP-1 as a … is poorly understood, with conflicting results being reported by …

… proofreading model of TCR ligand discrimination, and in … as a buffering zone, competing
interacting proteins with either … positive or negative feedback loop to further fine tune TCR …

… ) connecting TCR response to the MAP kinase pathway and Ca … a limiting role of SHP-1
interaction in favoring autoinhibited … , Erk also functions as a negative feedback regulator of TCR …

… the binding of SHP-1 (53). These results suggest that strong … the TCR signal strength-sensitive
PI3K/AKT/mTOR pathway … less likely to be out-competed by their high affinity counterparts (…

… TCR ligands only produce a short-lived, ineffective response). Introducing a … TCR ligand
discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways…

… on the physiological response of a T cell. The canonical TCR signaling pathway relies on …
also to the activation of negative regulatory mechanisms that stop early TCR signaling. These …

… in the presence of high levels of non-specific competition … of TCR signaling and its ability to
filter out non-specific ligands. … that weak ligands predominantly activate the negative (SHP-1) …

… , and with conflicting results concerning whether antagonism … inhibitory signaling pathways
depending on ligand affinity and … of KPR with negative feedback, including the loss of ligand …