… it binds to TDP-43 or whether this is a retention due to non-tau, non-TDP-43 related
neurodegeneration 19,20 . To further study whether 18 F-Flortaucipir binds to TDP-43 related …

… frontotemporal dementia (FTD). The pathomechanisms underlying abnormal mislocalisation
and aggregation of TDP-43 … and FTD relates specifically to TDP-43, posing the question as …

… morphology of nuclear TDP-43-depleted and TDP-43 inclusion-bearing neurons to determine
whether the reduction of nuclear TDP-43 alone is associated with neuronal degeneration. …

… for frontotemporal dementia … TDP-43 pathology, it typically has minimal TDP-43 pathological
burden that is limited to the motor cortex and thus often differs from other forms of TDP-43. …

… which consist of the TDP-43 protein are found within … and frontotemporal dementia (FTD).
The presence of these insoluble intracellular TDP-43 inclusions suggests that restoring TDP-43 …

… and frontotemporal lobar degeneration (FTLD). Here we constructed a conditional TDP-43
mouse with depletion of TDP-43 in … of age-dependent frontotemporal dementia-like behaviour …

… the evolution in understanding of frontotemporal dementia (FTD) during the … TDP-43
pathology, and speech or limb apraxia tau pathology. The co-occurrence of MND predicts TDP-43 …

… and GRN mutations are associated with TDP-43 aggregation, whereas mutations in MAPT
lead to tau aggregation.5 Within the molecular class TDP-43, 5 different histotypes (AE) have …

… TDP-43 aggregates are unknown. Here we used cryo-electron microscopy to determine the
structures of aggregated TDP-43 … 282–360 in the TDP-43 low-complexity domain and adopts …

… (TDP-43) and is termed FTLD-TDP 1,2. In addition to FTLD, pathological TDP-43 inclusions
… Clinical overlap between FTD and ALS 4,5 and involvement of extra-motor areas by TDP-43 …