De-mystifying the Fog: Assessment of Aerosol Exposure from Novel Nicotine Delivery Devices

ZR Dunbar - 2020 - search.proquest.com
… [146] Prior to excretion, nicotine metabolizes into cotinine via … In recent years, large
datasets of urinary cotinine data have … testing of urinary levels of TSNAs such as NNAL to track …

[PDF][PDF] The Effect of Chronic Cigarette Smoking on Some Kidney Function Markers

AE Emmanuel, MT MacPaul, OA Chukwuemeka - researchgate.net
… Results: Analysis of the data revealed that, as compared to … (TSNAs), some of the most
potent cancercausing agents … found that smokers had considerably higher mean urine albumin …

A review of nicotine‐containing electronic cigarettes—Trends in use, effects, contents, labelling accuracy and detection methods

A Taylor, K Dunn, S Turfus - Drug Testing and Analysis, 2021 - Wiley Online Library
… limit to buy and use these products, with 18 years being the most … is excreted unchanged in
the urine within 24 h while 10% is … The use of this artificial flavour may remove the TSNAs that …

[HTML][HTML] E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models

C Khachatoorian, W Luo, KJ McWhirter, JF Pankow… - Toxicology in Vitro, 2021 - Elsevier
… Our work demonstrated a clear increase in inflammatory marker secretion upon ALI exposure
of … Our data suggest a need for regulation of solvents in EC products and accumulation of …

[HTML][HTML] Electronic nicotine delivery systems (ENDS): a convenient means of smoking?

S Mariaelvina, C Gotti - Pharmacological Research, 2023 - Elsevier
… to smoking cessation, and recent epidemiological data … A few studies have reported the
presence of TSNAs in the cartridge … urine to monitor exposure to different carcinogens in ENDS. …

The use of imaging, biomonitoring and microdosing in human volunteers to improve safety assessments and clinical development

T Burt, RD Combes - The History of Alternative Test Methods in Toxicology, 2019 - Elsevier
… , distribution, metabolism and excretion, has traditionally been … -1-butanone (NNAL), the
urinary metabolite of the carcinogen, … , that data obtained with limited pharmacological exposure

The oral microbiome as a biological matrix for assessing tobacco-related exposures and biological effects in persons who use tobacco products

A Alcheva - 2023 - search.proquest.com
Tobacco-specific nitrosamines (TSNA) is another group of … NNN and its N-glucuronide
excreted in urine (total NNN).… Participants had to be 18 years old and smoke at least 5 cigarettes

Polycyclic aromatic hydrocarbons (PAHs) may explain the paradoxical effects of cigarette use on preeclampsia (PE)

JA Holme, H Valen, BC Brinchmann, GE Vist… - Toxicology, 2022 - Elsevier
… In addition, we extracted and presented data from the studies … 2) and tobacco-specific
nitrosamines (TSNA) in urine among … hypothesize that exposure to PAHs via cigarette smoke may …

Acrylamide levels in smoke from conventional cigarettes and heated tobacco products and exposure assessment in habitual smokers

F Esposito, J Squillante, A Nolasco, P Montuori… - Environmental …, 2022 - Elsevier
… The data showed a low neurotoxic risk for either CC or HTP, … significant association of
urinary acrylamide metabolites with … mice exposed to AA through drinking water for two years (…

Exposure, retention, exhalation, symptoms, and environmental accumulation of chemicals during JUUL vaping

M Hua, W Luo, C Khachatoorian… - Chemical Research …, 2023 - ACS Publications
… and altered plasma and urinary metabolites, which could … , nicotine alkaloids, tobacco
specific nitrosamines (TSNAs), … use ECs or tobacco cigarettes, who were at least 18 years old…