… for their SARS-CoV-1 cysteine protease inhibition activity. … inhibition of PLpro by tanshinones
and suggested the time-dependent inhibition mechanism for the possible slow binding …

… SARS-CoV-2 M pro and PL pro are cysteine proteases that … , it remains unknown whether
they can selectively bind to PL pro … , tanshinone I, dihydrotanshinone I, tanshinone IIA, and 6-…

… Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
Bioorg Med Chem 2012; 20(19): 5928-35. http://dx.doi.org/10.1016/j.bmc.2012.07.038 …

… with PLpro before the enzymatic reaction so that the slow-binding inhibitors will not be … The
two tanshinone derivatives not identified in our screen (cryptotanshinone and tanshinone IIA) …

… a selective and slow-binding inhibitory activity against SARS-CoV cysteine proteases 3CLpro
… Kinetic-mechanistic evaluations showed that all these tanshinones act as noncompetitive …

… Like Mpro, PLpro is a Cysteine protease, however both enzymes … reported Tanshinone
derivatives as inhibitors of SARS-CoV-2 … Tanshinones are compounds found naturally in the plant …

… Additionally, it has been found that tanshinones, which were isolated from Salvia miltiorrhiza,
are specific and selective inhibitors for the SARS-CoV 3CLpro and PLpro (Park JY et al. …

… Therefore, the purpose of this review is to evaluate inhibitors of SARS-CoV-2 3CL-protease
as … Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases. …

… six of these compounds selectively exhibited stronger inhibitory … They reported that seven
tanshinones derived from Salvia … In addition to TMPRSS2, an endosomal cysteine protease …

… Tanshinones (57–63), isolated from Salvia miltiorrhiza Bunge, were found to be time-dependent
selective inhibitors against the cysteine protease SARS-CoV … slow-binding inhibition. …