iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
… sources each possess advantages and disadvantages for use in cellular therapy targeting
cancer (30). Peripheral blood NK (PB-NK) cells must be collected from a donor by apheresis …

Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
… killing target cells autonomously, natural killer (NK) cells serve … lymphocytes, especially
restoring exhausted CD8 + cytotoxic … in blood and counting for about 5–10% of peripheral blood

[PDF][PDF] Multifunctional natural killer cell engagers targeting NKp46 trigger protective tumor immunity

L Gauthier, A Morel, N Anceriz, B Rossi… - Cell, 2019 - cell.com
… expressed on the lymphocytes infiltrating diverse types of human solid cancers (Figures 1A–…
intensity of NKp46 and CD16 staining for NK cells from peripheral blood (n = 24) and tumor …

Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy

Y Cao, X Wang, T Jin, Y Tian, C Dai… - … and targeted therapy, 2020 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes in the family of innate lymphoid … CD56
dim NK cells in the peripheral blood of approximately one-quarter of healthy humans. In ovarian …

Efficacy of third-party chimeric antigen receptor modified peripheral blood natural killer cells for adoptive cell therapy of B-cell precursor acute lymphoblastic leukemia

C Quintarelli, S Sivori, S Caruso, S Carlomagno… - Leukemia, 2020 - nature.com
… NK cells with CAR targeting CD19-expressing leukemia cells, … of human lymphoma, we show
that CAR-modified, PB NK cellscells against NK-cell resistant primary chronic lymphocytic

[HTML][HTML] Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells

M Carlsten, M Järås - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes … lyse target cells via antibody-dependent
cellular cytotoxicity, a … Ex vivo expanded peripheral blood NK cells can prevent leukemia …

[HTML][HTML] Cancer immunotherapy based on natural killer cells: current progress and new opportunities

W Hu, G Wang, D Huang, M Sui, Y Xu - Frontiers in immunology, 2019 - frontiersin.org
… Direct cytotoxicity for target cells by NK cells is thought to critically rely on cytolytic granules
… Second, the quantity of NK cells and NKT cells among peripheral blood lymphocytes count …

The emergence of natural killer cells as a major target in cancer immunotherapy

F Souza-Fonseca-Guimaraes, J Cursons… - Trends in …, 2019 - cell.com
… the activity of tumor-resident cytotoxic lymphocytes and have revolutionized cancer …
lymphocytes. It also outlines emerging approaches aimed at unleashing the potential of NK cells

Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells

LD Uppendahl, M Felices, L Bendzick, C Ryan… - Gynecologic …, 2019 - Elsevier
… , natural killer (NK) cells are lymphocytes well suited for adoptive immunotherapy due to their
ability to kill target cells … Use of peripheral blood mononuclear cells (PBMCs) from donors …

Dysregulation of natural killer cells in obesity

D O'Shea, AE Hogan - Cancers, 2019 - mdpi.com
Natural killer cells are a subset of innate lymphocytes, which play a very important role in …
result in the activation of NK cells, and the lysis of the target cell. Natural Killer cells can also be …