[HTML][HTML] Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
… peripheral blood lymphocytes against tumor- or virus-infected cells was first observed in mice
and humans … Target cell elimination is mediated directly by cytotoxic pathways, or indirectly …
and humans … Target cell elimination is mediated directly by cytotoxic pathways, or indirectly …
[HTML][HTML] Natural killer cells as key players of tumor progression and angiogenesis: old and novel tools to divert their pro-tumor activities into potent anti-tumor effects
… Natural killer (NK) cells are effector lymphocytes involved in … -associated NK cells (TANK
cells) in peripheral blood and … approaches aimed at potentiating/restoring NK cell activities …
cells) in peripheral blood and … approaches aimed at potentiating/restoring NK cell activities …
[HTML][HTML] Human gut-associated natural killer cells in health and disease
… on NK cells isolated from peripheral blood mononuclear cells (… vitro against conventional
NK cell targets, but rather produce … + cytotoxic lymphocytes infiltration, and intraepithelial Th17 …
NK cell targets, but rather produce … + cytotoxic lymphocytes infiltration, and intraepithelial Th17 …
[HTML][HTML] High cytotoxic efficiency of lentivirally and alpharetrovirally engineered CD19-specific chimeric antigen receptor natural killer cells against acute lymphoblastic …
S Müller, T Bexte, V Gebel, F Kalensee… - Frontiers in …, 2020 - frontiersin.org
… engineering of peripheral blood (PB) derived NK cells remains … , we aimed to optimize the
generation of CD19-CAR-NK cells by … Natural killer (NK) cells are cytolytic lymphocytes that …
generation of CD19-CAR-NK cells by … Natural killer (NK) cells are cytolytic lymphocytes that …
Memory-like natural killer cells for cancer immunotherapy
M Gang, P Wong, MM Berrien-Elliott… - Seminars in hematology, 2020 - Elsevier
… with adaptive T and B lymphocytes. However, a large body of … cells also mediate
contact-dependent killing of target cells … NK cells are the major mature population in peripheral …
contact-dependent killing of target cells … NK cells are the major mature population in peripheral …
OMIP‐069: forty‐color full spectrum flow cytometry panel for deep immunophenotyping of major cell subsets in human peripheral blood
LM Park, J Lannigan, MC Jaimes - Cytometry Part A, 2020 - Wiley Online Library
… NKG2A (CD159a), identified as a possible target for immunotherapy (30), and the activation
… of lymphocytes, monocytes, and dendritic cells present in human peripheral blood. It covers …
… of lymphocytes, monocytes, and dendritic cells present in human peripheral blood. It covers …
[PDF][PDF] Human CD96 correlates to natural killer cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
H Sun, Q Huang, M Huang, H Wen, R Lin… - …, 2019 - Wiley Online Library
… on the cytotoxicity of peripheral blood mononuclear cells (PBMCs… on different target
cells and found that hepatoma cell line HepG2 … Blocking antibodies targeting cytotoxic T-lymphocyte–…
cells and found that hepatoma cell line HepG2 … Blocking antibodies targeting cytotoxic T-lymphocyte–…
[HTML][HTML] Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
K Shankar, CM Capitini, K Saha - Stem cell research & therapy, 2020 - Springer
… of perforin and granzyme B to kill target cells [35]. … from peripheral blood lymphocytes often
results in a heterogenous population of lymphocytes with only a 10–20% yield of NK cells [55]…
results in a heterogenous population of lymphocytes with only a 10–20% yield of NK cells [55]…
[HTML][HTML] Overcoming resistance to natural killer cell based immunotherapies for solid tumors
G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
… the targeted increase in the density of NK cells and lymphocytes in … To increase the targeting
specificity of expanded NK cells, … activities of peripheral blood natural killer cells modified by …
specificity of expanded NK cells, … activities of peripheral blood natural killer cells modified by …
Natural killer cells and anti-tumor immunity
SE Nicholson, N Keating, GT Belz - Molecular immunology, 2019 - Elsevier
… Immunotherapies that target inhibitory receptors on immune cells, such as programmed
cell-death protein 1 (PD1) and cytotoxic T-lymphocyte protein 4 (CTLA-4), have dramatically …
cell-death protein 1 (PD1) and cytotoxic T-lymphocyte protein 4 (CTLA-4), have dramatically …