OMIP‐069: forty‐color full spectrum flow cytometry panel for deep immunophenotyping of major cell subsets in human peripheral blood

LM Park, J Lannigan, MC Jaimes - Cytometry Part A, 2020 - Wiley Online Library
… NKG2A (CD159a), identified as a possible target for immunotherapy (30), and the activation
… of lymphocytes, monocytes, and dendritic cells present in human peripheral blood. It covers …

[PDF][PDF] Human CD96 correlates to natural killer cell exhaustion and predicts the prognosis of human hepatocellular carcinoma

H Sun, Q Huang, M Huang, H Wen, R Lin… - …, 2019 - Wiley Online Library
… on the cytotoxicity of peripheral blood mononuclear cells (PBMCs… on different target
cells and found that hepatoma cell line HepG2 … Blocking antibodies targeting cytotoxic T-lymphocyte–…

Targeting glycosylated antigens on cancer cells using siglec‐7/9‐based CAR T‐cells

S Meril, O Harush, Y Reboh, T Matikhina… - Molecular …, 2020 - Wiley Online Library
… on immune cells, such as natural killer cells, T-cells, and dendritic cells and they … Peripheral
blood lymphocytes (PBLs) used in this study were from healthy donors from the Israeli Blood

[HTML][HTML] Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

K Shankar, CM Capitini, K Saha - Stem cell research & therapy, 2020 - Springer
… of perforin and granzyme B to kill target cells [35]. … from peripheral blood lymphocytes often
results in a heterogenous population of lymphocytes with only a 10–20% yield of NK cells [55]…

[HTML][HTML] Overcoming resistance to natural killer cell based immunotherapies for solid tumors

G Nayyar, Y Chu, MS Cairo - Frontiers in oncology, 2019 - frontiersin.org
… the targeted increase in the density of NK cells and lymphocytes in … To increase the targeting
specificity of expanded NK cells, … activities of peripheral blood natural killer cells modified by …

Natural killer cells and anti-tumor immunity

SE Nicholson, N Keating, GT Belz - Molecular immunology, 2019 - Elsevier
… Immunotherapies that target inhibitory receptors on immune cells, such as programmed
cell-death protein 1 (PD1) and cytotoxic T-lymphocyte protein 4 (CTLA-4), have dramatically …

Novel CD19-targeted TriKE restores NK cell function and proliferative capacity in CLL

M Felices, B Kodal, P Hinderlie, MF Kaminski… - Blood …, 2019 - ashpublications.org
… the inflammatory function of NK cells obtained from CLL patient peripheral blood samples.
Finally, we … are innate immune effectors comprising 5% to 15% of blood lymphocytes that are …

Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells

CH Wu, J Li, L Li, J Sun, M Fabbri… - Journal of …, 2019 - Taylor & Francis
human NK cells and cytotoxic T lymphocytes release these … Peripheral blood mononuclear
cells (PBMC) were isolated by … ), and T-cells were then absorbed using a human CD3 positive …

[HTML][HTML] DNAM-1 and the TIGIT/PVRIG/TACTILE axis: novel immune checkpoints for natural killer cell-based cancer immunotherapy

B Sanchez-Correa, I Valhondo, F Hassouneh… - Cancers, 2019 - mdpi.com
… In humans, peripheral blood NK cells can be … for human T cells [29] and NK cells [28]. PVRIG
binds with high affinity to its ligand CD112 on target cells suppressing lymphocyte cytotoxic

[HTML][HTML] The role of natural killer cell in gastrointestinal cancer: killer or helper

F Wang, JKC Lau, J Yu - Oncogene, 2021 - nature.com
… , natural killer (NK) cells can swiftly target and lyse tumor cells … In addition to the cytotoxic T
lymphocytes, many other immune cell … the immune cells of peripheral blood mononuclear cell (…