… of heart failure, and gene transfer therapies aimed at restoring … In failing human hearts,
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …

… In the heart, the sarcoplasmic reticulum (SR) is a Ca 2+ … In addition, we will also cover the
recent gene therapy of … of SERCA2a as a research target for heart failure treatment. Kho [55] …

… Studies in failing hearts have also shown that decreased SERCA expression or activity is …
Under normal conditions and stable heart rate, diastolic SR Ca 2+ load varies little from beat to …

… + cycling, Ca 2+ leak from the sarcoplasmic reticulum and … SERCA2a) gene transfer
successfully restored the Ca 2+ … TRPC3 overexpressing hearts were also more susceptible to …

… (sarcoplasmic/endoplasmic reticulum calcium ATPase 2a) as a … Restoration of cardiac calcium
homeostasis is an attractive … targeting SUMOylation of SERCA2a through gene transfer of …

… Phase 1 and 2a human trials, in which the SERCA2a gene was … SUMOs covalently attach
to a target protein through a specific … gene therapy of sarcoplasmic reticulum Ca2+-ATPase in …

… AF can be treated with antiarrhythmic drug therapy, direct … + release channels (RyR) in
the sarcoplasmic reticulum (SR)… of its direct target, Acetyl-CoA carboxylase (ACC) (Figure 8). …

… clinical study of gene therapy with AAV1/sarcoplasmic reticulum calcium ATPase 2a (AAV1/…
CMs are largely nondividing and are therefore promising targets for therapeutic AAV vectors. …

… aimed at preventing cardiac arrhythmias in cardiac disease. … with the pro-oxidant hormone
angiotensin II. After 3 weeks of … used for drug delivery places this type of therapy in the …

… Ca 2+ is primarily stored within the sarcoplasmic reticulum (… using small molecule inhibitors
or gene therapy approaches. … stimulation and its downstream PKA first target LTCCs [4]. …