… + from the sarcoplasmic reticulum by the ryanodine receptors … -mediated Ca 2+ buffering
capacity by gene transfer of … -targeted genetic Ca 2+ probes and in vivo delivery methods …

… efforts of gene therapy approaches for the VAs that target ion … ), and sarcoplasmic reticulum
(SR) Ca 2+ ATPase pump (… gene therapy reached clinical phase II study but failed due to …

… decompensated heart failure, and antiarrhythmic drug therapy or … such as stereotactic radiation
therapy, that target the arrhythmic … phosphorylates the sarcoplasmic reticulum (SR) Ca 2+ …

… examine HFrEF therapy aimed at improving cardiac function … of Ca 2+ into the SR through
sarcoplasmic reticulum Ca 2+ … mediated gene therapy halted the progression of heart failure in …

… with acute myocardial ischaemia or heart failure — can have an … as a potential therapeutic
target and highlight technical … MHC class II and CCR2 and express conduction-related genes, …

… and sarcoplasmic reticulum (SR) Ca 2+ -ATPase 2a … intervention have focused on viral-mediated
gene delivery using … of HF, viral βARKct gene delivery restored myocardial β-AR …

… therapy is a promising gene delivery platform for cardiac … of gene delivery assisted by viral
vectors, the target gene must … function by overexpressing a target molecule [13, 29], (ii) loss of …

… , we discuss gene therapy approaches for cardiac disease. … The first cardiac gene therapy
attempts aimed to promote … mediates Ca 2+ uptake into the sarcoplasmic reticulum in …

… a massive Ca 2+ release from the sarcoplasmic reticulum (SR… Gene therapy targeting
SERCA2a was tested in the calcium … -heart-kidney regulator of cardiac Ca 2+ handling (Panel II, …

… the sarcoplasmic reticulum (SR) lumen to maintain SR Ca2+ … , the Ca2+ pump has become
a promising therapeutic target … Although SERCA2a gene therapy showed promising results …