… phosphorylated-Ca 2+ /calmodulin-dependent protein kinase II in … (RyR2) -mediated
sarcoplasmic reticulum (SR) Ca 2+ leakage [… of Ca 2+ handling by targeted SERCA2a gene …

… sarcoplasmic reticulum (SR) plays the key role in cardiac … Importantly, inhibition of ERO1α
was able to restore intra-SR … , as off-target effects in organs other than the heart can be avoided…

… associated with AAV and drug delivery, the limitation of free … , causes reduced sarcoplasmic
reticulum (SR) Ca 2+ release, … the advantage to target both skeletal and cardiac muscles, …

… Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability
in the failing heart. Circulation 2012; 126 (17): 2095–104. Stefenelli T, Wikman‐Coffelt J, …

… ) is a protein in the sarcoplasmic reticulum membrane that … to repair the genetic defect (eg
antisense and gene therapy), … expression of a stable dystrophin gene. Functional assessment, …

… may benefit from combining gene-targeted therapies with small … may also come from the
sarcoplasmic reticulum (SR) in … viral gene delivery, the pursuit of a DMD gene therapy faces …

… NCX blocker restores the sarcoplasmic reticulum (SR) Ca2+ … largest gene transfer clinical
studies (CUPID2), targeting the … channels are packaged in coatomer protein II (COPII) vesicles. …

… therapy is a promising gene delivery platform for cardiac … of gene delivery assisted by viral
vectors, the target gene must … function by overexpressing a target molecule [13, 29], (ii) loss of …

… sarcoplasmic reticulum in the cardiomyocytes and decreases … that SERCA2a is not only a
target of the insulin−PKB … ], which can be enhanced through gene transfer of SUMO-1 or small …

… tissues after TAC and a restoration by administration of rAAV9-… Ca 2+ and the decrease in
mitochondrial Ca 2+ in Ang II-… miRNA in the heart by targeting Mfn2. Overexpression of miR-…