S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models
D Kehr, J Ritterhoff, M Glaser, L Jarosch, RE Salazar… - bioRxiv, 2023 - biorxiv.org
… , where it resides at the sarcoplasmic reticulum (SR), the … pipette 48 or from cardiac-targeted
S100A1 overexpression in … -based S100A1 gene therapy in post-MI cardiac disease models …
S100A1 overexpression in … -based S100A1 gene therapy in post-MI cardiac disease models …
[HTML][HTML] Roles and mechanisms of quercetin on cardiac arrhythmia: A review
Y Zhou, W Suo, X Zhang, J Lv, Z Liu, R Liu - Biomedicine & …, 2022 - Elsevier
… and molecular targets of quercetin in cardiac arrhythmia caused … Among them, nanotechnology
is promising for drug delivery … Ca 2+ relies on the sarcoplasmic reticulum Ca 2+ -ATPase …
is promising for drug delivery … Ca 2+ relies on the sarcoplasmic reticulum Ca 2+ -ATPase …
[HTML][HTML] … the sarcolemma and intracellular organelles in Duchenne muscular dystrophy: A role in the dysregulation of ion homeostasis and a possible target for therapy
MV Dubinin, KN Belosludtsev - International Journal of Molecular …, 2023 - mdpi.com
… and, in particular, stable calcium levels necessary for normal … aimed at creating a gene
therapy that allows restoration of … are talking about the sarcoplasmic reticulum and mitochondria. …
therapy that allows restoration of … are talking about the sarcoplasmic reticulum and mitochondria. …
[HTML][HTML] Natural and synthetic antioxidants targeting cardiac oxidative stress and redox signaling in cardiometabolic diseases
M Barteková, A Adameová, A Görbe… - Free Radical Biology …, 2021 - Elsevier
… associated with heart failure or electrical instabilities are … from treatments aimed to restore
cardiac redox homeostasis. … and electrical instability which manifest as impaired cardiac …
cardiac redox homeostasis. … and electrical instability which manifest as impaired cardiac …
From atoms to cells: Bridging the gap between potency, efficacy, and safety of small molecules directed at a membrane protein
R Aguayo-Ortiz, J Creech, EN Jiménez-Vázquez… - bioRxiv, 2021 - biorxiv.org
… cardiac Ca 2+ pump (Sarcoplasmic reticulum Ca 2+ -ATPase… that encompasses drug delivery,
target engagement, cellular … that can be targeted for therapeutic modulation (ii) designing …
target engagement, cellular … that can be targeted for therapeutic modulation (ii) designing …
[HTML][HTML] Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium …
… dependent protein kinase II (CaMKII) and improve Ca 2+ handling in … , the Ca 2+ content of
the sarcoplasmic reticulum ([Ca 2+ ] … heart [63, 64], whereas targeted SERCA2a gene transfer …
the sarcoplasmic reticulum ([Ca 2+ ] … heart [63, 64], whereas targeted SERCA2a gene transfer …
Oxidation of Ryanodine Receptors Promotes Ca2+ Leakage and Contributes to Right Ventricular Dysfunction in Pulmonary Hypertension
Y Huang, C Lei, W Xie, L Yan, Y Wang, S Yuan… - …, 2021 - Am Heart Assoc
… 2) on sarcoplasmic reticulum (SR) and aberrant Ca 2+ cycling … and hypertrophic target
genes. CaMKII not only changes the … The drug achieves the stabilization effect by binding to the …
genes. CaMKII not only changes the … The drug achieves the stabilization effect by binding to the …
Genetic Determinant of familial dilated cardiomyopathy and genotype-targeted therapeutic strategy
J Zhong, LP Li, JF Zhou, YH Ding - … -Novel Aspects of Cardiac …, 2020 - books.google.com
… kinase II delta (CAMK2D) is another pivotal cardiac gene … inhibiting the sarcoplasmic reticulum
Ca2+-ATPase (SERCA2a)… of gene delivery and restoration of dystrophin gene function [65…
Ca2+-ATPase (SERCA2a)… of gene delivery and restoration of dystrophin gene function [65…
[HTML][HTML] German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia …
… -release events from the sarcoplasmic reticulum (SR) through … to slowed conduction, and
that gene transfer of connexin-43 … targeting the mechanisms underlying slow conduction [22]. …
that gene transfer of connexin-43 … targeting the mechanisms underlying slow conduction [22]. …
[HTML][HTML] MicroRNA-20b promotes cardiac hypertrophy by the inhibition of mitofusin 2-mediated inter-organelle Ca2+ cross-talk
Y Qiu, R Cheng, C Liang, Y Yao, W Zhang… - Molecular Therapy …, 2020 - cell.com
… tissues after TAC and a restoration by administration of rAAV9-… Ca 2+ and the decrease in
mitochondrial Ca 2+ in Ang II-… miRNA in the heart by targeting Mfn2. Overexpression of miR-…
mitochondrial Ca 2+ in Ang II-… miRNA in the heart by targeting Mfn2. Overexpression of miR-…