… and apoptosis in the testis. The objective of this study was to determine the effects of the
anti-obesity drug orlistat, on testicular oxidative stress, inflammation and apoptosis in high-fat …

… have shown that orlistat can induce tumor cells apoptosis by targeting certain signaling pathways
… cells, resulting in decreased fatty acid metabolism and G1 stagnation of cell cycle. [ 22 ] …

… The role of pancreatic lipase inhibitor in lipid metabolism is elaborated. … Lipase inhibitors
have become an important means of clinical obesity treatment. In Table 1, we list that orlistat …

… target enzymes (for example, ACAC, ACLY, SCD1, etc.) that functionally contribute to the
tumorigenic properties of lipid… associated lipid metabolism by affecting multiple lipogenic targets …

… , orlistat could be useful to ameliorate the progression of atherosclerosis in obesity. The
disorder of lipid metabolism … Our results suggest that orlistat might play a role in the process of …

… Caspase-3 staining revealed a decrease in apoptosis due to … In order to put our findings on
lipases and orlistat in a clinical context… , holds promise for identifying novel therapeutic targets …

… to cell death by apoptosis, necrosis or autophagy [4]. … inhibit lipoprotein lipase activity
upon binding to an effector site of the protein [52] and to inhibit FASN by acting as a multi-targeted …

… leukemia, orlistat induces dose-dependent apoptosis, but the … Moreover, since several
newly-developed targeting drugs … analyzing the combined effects of orlistat with dexamethasone (…

… the distinct lipid metabolism in tumour cells, inhibitors targeting … , induce apoptosis, and
prevent cell proliferation. These … of FASN inhibitors on cell viability, we found that Orlistat elicited …

… Both FASN knockdown and orlistat treatment induced cell apoptosis. Mechanistically, …
between lipid metabolism and GBC progression, we focused on a potential target, FASN, by …