… apicomplexan parasites. This chapter reviews our current knowledge of purine and pyrimidine
metabolic … potential of targeting the purine auxotrophy of apicomplexan parasites to inhibit …

… considered a good drug target given that benzamidine- and melamine-coupled compounds
can be targeted to the … The apicomplexans, like many other protozoa, are able to synthesize …

… -aspartate (precursors of purine and pyrimidine biosynthesis, respectively), … targeting the
parasite’s metabolism. Moreover, by comparing the genomes of species within the Apicomplexa …

… This review highlights the main metabolic pathways targeted for … parasites of the Plasmodium
genus in the Apicomplexa phylum… family, targeting proteins involved in purine or pyrimidine …

… of either preformed purine bases or purine nucleosides from … for pyrimidines although in some
cases, several pyrimidine … as drug targets in kinetoplastid and apicomplexan parasites. We …

… purine catabolism via … target other apicomplexan parasites. The potent antimalarial activities
of PanAms show that the Pan and CoA synthesis pathways are indeed plausible drug targets…

… Purine metabolism has been a target for novel antimalarial … the apicomplexan parasite is
unable to undergo de novo purine … purine and pyrimidine synthesis in Plasmodium parasites an …

… Malaria is caused by the apicomplexan parasite, Plasmodium sp . The five main species
able to cause disease in humans are Plasmodium falciparum, Plasmodium vivax, Plasmodium …

… might also be encoded by other enzymes, eg, purine … Pyrimidine metabolic pathways in blood
parasites can be … cytidine kinase activity in apicomplexan parasites, including Plasmodium …

… structurally related purines and pyrimidines in a target-agnostic … Since purine derivatives
aim to target parasites purine salvage … Apicomplexan parasite cultures were maintained at 3% …