… PI3K/Akt/mTOR oncogenic signaling in cancer and provide insights into possible future
directions for targeted … combination regimen to target the PI3K/Akt/mTOR signaling pathway. This …

… PI3K/mTOR signaling components have been prime targets … genetic disorders induced by
mutations of the PI3K signaling … efficacy, but potentially bringing PI3K signaling back to normal …

… the PI3K/AKT/mTOR pathway is often genetically altered in … inhibitors targeting the PI3K/AKT/mTOR
signaling pathway … to determine the potential benefit of inhibiting PI3K in HER2+ …

… cancers.34, 35 Gene mutations in the Akt family which encode Akt1… signaling effects of the
PI3K/Akt/mTOR pathway on the development and progression of malignancy, and its potential …

… PAM signaling pathway in cancer, and discuss the results of PI3K, AKT and mTOR inhibitors
… of resistance to PAM signaling targeted therapies, including PAM signaling in immunology …

… stemness, the PI3K/Akt/mTOR pathway has emerged as a potential therapeutic … genetic
alterations in the PI3K-AKT pathway [20]. Apart from the cancer initiation events, PI3K/Akt/mTOR …

… adaptive signaling changes. This could involve more invasive management before and
after treatment to determine the basis of each patient’s tumor genetics and signaling changes, …

… ; (4) mutations of the p53 pathway or alteration of the B-cell … potential anti-tumor effects
and excellent clinical application … potential dual functions of autophagy regulated by PI3K/AKT/…

… on the potential of natural products targeting PI3K-Akt-mTOR … -2 was done by using
targeted exome sequencing, mainly of … mutations or any other genetic alterations in PI3K-Akt-mTOR …

… the genetic alterations in normal patients and tumor patients and discuss the role of targeted
… in carcinoma initiation and tumor development as potential strategies for tumor therapy, …