… Herein, we review innovative immunotherapeutic strategies and their mechanisms of action
… therapeutic targets for redirecting the leukemic immunosuppressive microenvironment into a …

… targeting PD-1, PD-L1, CTLA-4, and newer targets such as TIM3 and STING). The current
and future directions of these T-cell-based immunotherapies … the tumor microenvironment and …

… acute lymphoblastic leukemia and large B cell lymphoma. Novel indications and integration
of immunotherapy … To optimize the tumor microenvironment, we must first understand what …

… In this Review we discuss the hurdles of finding suitable targets for AML immunotherapy,
summarize the immune features of the leukemia microenvironment, review results obtained in …

… of immune escape, and lack of consensus in defining the AML tumor microenvironment. …
TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell Stem Cell 7:…

… of the solid tumor microenvironment (TME) … to immunotherapy. Computational tools are
incessantly being developed to characterize tumor-infiltrating immune cells and to model tumor …

… acute lymphoblastic leukemia [5] and B cell lymphomas [6], they have been less effective in
AML due to the lack of a direct antigen target. … niche or tumor microenvironment plays a major …

… This is one of several mechanisms by which the AML tumor microenvironment may alter …
novel target antigens for personalized immunotherapy and vaccines. Thus, in the near future…

… leukemic clonal evolution. Accordingly, they have been considered as ideal targets for AML
immunotherapy … effects induced by AML microenvironment in dampening the therapeutic …

… and possibly predicting resistance to immunotherapy [78]. On this … on Tregs in the cancer
microenvironment. The frequent co-… -targeting LAG-3 is currently being tested in solid tumors, …