… and supplies a pathway for distant metastasis. Angiogenesis represents … Vascular endothelial
growth factor (VEGF) is a major … that first-line bevacizumab combination therapy effectively …

… that the vascular endothelial growth factor pathway is an … ) that target vascular endothelial
growth factor receptors (VEGFRs) … as first-line treatments for metastatic RCC; axitinib treatment …

… Novel treatments consist of molecularly targeted agents … In the 1990s and early 2000s,
treatment of metastatic disease … with progressive disease after first-line therapy in 2012. Axitinib …

… its potential for growth and distant metastasis. The main … , is a target for biological drugs
such as multi-targeted tyrosine … nine months of the start of first-line treatment; 2) in all patients …

… In 1989, we reported the isolation and cDNA cloning of vascular endothelial growth factor (…
, and carboplatin, for the first-line treatment of patients with metastatic, non-squamous NSCLC …

… therapeutic agents targeting VEGF and VEGF receptors have … setting, EGFR TKIs have
been established as first-line therapy … VEGF, vascular endothelial growth factor; VEGFR, VEGF …

… target the vascular endothelial growth factor receptor (VEGFR) have become the backbone
in the first-line treatment for patients with metastatic … for the first-line and second-line therapy …

… of targeting angiogenesis via the vascular endothelial growth … VEGFR2 (vascular endothelial
growth factor receptor 2), the … (as maintenance therapy after a first line of treatment for …

… that treatments targeting the VEGFC signaling pathway inhibit the proliferation of endothelial
… The treatment of ccRCC in the first-line of the metastatic disease was implemented by the …

… growth and metastatic spread, inhibition of angiogenesis by targeting the vascular endothelial
growth factor … However, patient outcomes after first-line treatment remain poor with a …