… An elevated plasma Lp(a) level, primarily determined by a … apo(a) isoform size is a major
determinant of Lp(a) levels, little is known about the relationship between apo(a) size variability …

… the smaller LPA allele leading to expression at the apo(a) level [… of genomic variation in
LPA gene with plasma Lp(a) levels in … However, these are not the sole determinants and future …

… the genetic and biological basis for variation in Lp(a) levels and … as the central determinants
of atherogenesis and risk for … between apo(a) isoform size and plasma Lp(a) levels. However…

… a variation would be related to differences in Lp(a) levels is … nonrepeating antigenic
determinants on the apo(a) molecule. … for plasma Lp(a) level (Figure 3A), and then for Lp(a)‐OxPL …

… Thus, the LPA locus explained almost all of the total genetic variance of … LPA allele size
variability, plasma Lp(a) in most individuals consists of two particle populations with different apo(…

… The LPA gene coding apolipoprotein(a) (apo[a]) is located … The primary determinant of
differences in Lp(a) levels among … Lp(a) levels and may partially explain some of this variability. …

… the variance in plasma concentrations, while variants in LPA … Different findings were reported
in African Americans with an … the size of apo(a) may be an independent determinant of the …

… with higher plasma lipoprotein(a)[Lp(a)] concentrations or smaller … is the most important
predictor of variations in Lp(a) … The most important size determinant for apo(a) isoforms is the …

… that the increase in Lp(a) levels varies across apo(a) sizes as only patients with large size …
beyond its plasma level will help improve our understanding of non-genetic influences on Lp(a…

… apo(a) and thereby reducing plasma Lp(a) levels are in clinical trials. Their results will
determine if reductions in apo(a) and Lp(a) … The LPA gene is derived from a duplication of the …