Roles of E6 and E7 human papillomavirus proteins in molecular pathogenesis of cervical cancer

E Taghizadeh, S Jahangiri, D Rostami… - Current Protein and …, 2019 - ingentaconnect.com
… genomic DNA of HPV16 from cervical cancer cells has the … The obtained data also indicates
that the tumor resistance to … cervical cancer can be treated by surgery or the radiation, …

[HTML][HTML] Nimotuzumab combined with irradiation enhances the inhibition to the HPV16 E6-promoted growth of cervical squamous cell carcinoma

Z Xu, H Shu, F Zhang, W Luo, Y Li, J Chu… - Frontiers in …, 2020 - frontiersin.org
… and radiation remarkably reduced the protein expression … ; HPV16 causes about 55% of
cervical cancer cases; HPV16resistance caused by radiation (39). Importantly, nimotuzumab …

[HTML][HTML] HPV transcript expression affects cervical cancer response to chemoradiation

FJ Ruiz, M Inkman, R Rashmi, N Muhammad… - JCI insight, 2021 - ncbi.nlm.nih.gov
… correlates with resistance to radiation in cervical cancer cells, … HPV 16 E6 and E6* protein
coding sequences were ligated into … and E6* from HPV 16, we demonstrate that transcript …

[HTML][HTML] Role of the JAK/STAT pathway in cervical cancer: its relationship with HPV E6/E7 oncoproteins

A Gutiérrez-Hoya, I Soto-Cruz - Cells, 2020 - mdpi.com
… in the HPV16+ and HPV18+ cervical cancer cell lines … of SOCS1 in cervical tumor cells
confers radioresistance [160]. … , which reduce the resistance of cervical tumor cells to cisplatin …

[HTML][HTML] Human papillomaviruses as infectious agents in gynecological cancers. oncogenic properties of viral proteins

DA Haręża, JR Wilczyński, E Paradowska - International journal of …, 2022 - mdpi.com
… role of STAT1 in cervical cancer, especially in cervical lesions. … samples compared to resistant
cases suggest that STAT1 may … with HPV16 E6 and E7 expression in keratinocytes and in …

Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer

A Kumar, E Rathi, RC Hariharapura… - Medicinal research …, 2020 - Wiley Online Library
… target HPV16 E6 protein. In comparison to previously reported synthetic peptides, one of
the antibodies (GTE6-1) had a high affinity of 60 nM for HPV16 E6 protein and suppressed E6-…

[HTML][HTML] Molecular pathways in the development of HPV-induced cervical cancer

FR Bonab, A Baghbanzadeh, M Ghaseminia… - EXCLI …, 2021 - ncbi.nlm.nih.gov
… and the development of human cervical cancer. E6 and E7 proteins of HPV have a
pivotal role … Previous studies show the ability of HPV 16 E6 to cooperate with E6AP in Wnt/β-catenin …

[HTML][HTML] HPV16 E6 enhances the radiosensitivity in HPV-positive human head and neck squamous cell carcinoma by regulating the miR-27a-3p/SMG1 axis

D Long, L Xu, Z Deng, D Guo, Y Zhang, Z Liu… - … Agents and Cancer, 2021 - Springer
… , E6 promotes cell proliferation, apoptosis resistance and … apoptosis of cervical cancer, gastric
cancer and colon cancer cells [… mechanism of HPV16 E6 in HNSCC radiation therapy and …

Biology of the radio-and chemo-responsiveness in HPV malignancies

MT Spiotto, CM Taniguchi, AH Klopp, LE Colbert… - Seminars in radiation …, 2021 - Elsevier
HPV16 E6 in the HPV-negative C33 cervical cancer cell line increased resistance to
radiation… The HPV oncoprotein E6 oncoprotein can bind to XRCC1, a protein required for single …

Cellular functions of HPV16 E5 oncoprotein during oncogenic transformation

L Gutierrez-Xicotencatl, A Pedroza-Saavedra… - Molecular Cancer …, 2021 - AACR
… as is the case in the cervical cancer cell lines CasKi and SiHa (… protein was observed in all
of the HSIL and cervical cancer … , tumor progression, metastasis, and therapeutic resistance by …