… E7 degrades Rb protein and results in the overexpression of p16. P16 … In addition, HPV 16
tumors are more likely to have early … in killing tumors, is associated with radiation resistance. …

… as is the case in the cervical cancer cell lines CasKi and SiHa (… protein was observed in all
of the HSIL and cervical cancer … , tumor progression, metastasis, and therapeutic resistance by …

… squamous cell carcinoma and HPV-16 accounts for over 90% … of HPV-induced cervical
cancer [4]. The viral oncoproteins … radiation doses (2, 4 and 6Gy) and demonstrated resistance to …

… E6 and E7 proteins from diverse HPV types interact … cells of a MAGI-1 mutant resistant to E6
targeting can induce … Other phosphorylation sites in E7 have also been reported: in HPV-16 …

… cancer cells transduced with HPV16 E6 and/or E7 or firefly luciferase (control) were exposed
to 0, 2 or 4 Gy irradiation… DNA damage/repair proteins targeted by HPV16 E6 and/or E7 are …

… HPV-16 and HPV18 can integrate the viral genome into the … of protein-associated thiol groups
in cervical adenocarcinoma … Chemo/radioresistance of CC cells is also related to the redox …

… , we conclude that E6 from HPV16 and HPV18 increase the … that E6 enhances OS and DNA
damage in cervical cancer [… death in the presence of ionizing radiation. Therefore, in order to …

… knockout of HPV18 E6 or E7 proteins rendered … resistance as common control (Ctrl-1) and
as a specificity control we used a PX459 vector expressing gRNAs targeting HPV16 E6 or E7 …

… of female cancer worldwide, and cervical cancer is almost … HPV-16 E7 is a 98-amino acid-long
heterogenous protein … ultraviolet (UV)-B radiation-mediated apoptosis. The attenuation of …

… proteins differentially modulate epithelial-mesenchymal transition in 5-FU-resistant cervical
cancer … Ribozyme targeting HPV16 E6E7 transcripts in cervical cancer cells suppresses cell …