E6/E7 Oncogenes Mutation of Human Papillomavirus Type 16 Associated with P16 Protein Expression in Cervical Cancer

INB Mahendra, ING Budiana, IGM Putra… - European Journal of …, 2023 - ej-med.org
… conducted on cervical cancer women … radiation therapy. Willing to participate in the study
after signing the informed consent. Cervical tissue samples with a positive test result for HPV 16

Brd4 inhibition suppresses HPV16 E6 expression and enhances chemoresponse: A potential new target in cervical cancer therapy

O Rataj, J Haedicke‐Jarboui… - … Journal of Cancer, 2019 - Wiley Online Library
… advanced cervical carcinoma is a combination of γ irradiation … and E6/E7 expression, is the
cellular bromodomain protein Brd4.… role of E6 in the cisplatin resistance of cervical cancer cell …

HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

Q Peng, L Wang, L Zuo, S Gao, X Jiang, Y Han… - Cancer gene …, 2024 - nature.com
… Here, we summarized that E6 and E7 proteins promote HPV-… In cervical cancer, HPV16/18
E6 and E7 can regulate … HER3 and HPV16, E6 and E7 modulates drug resistance to PI3K …

AIB1 is a novel target of the high‐risk HPV E6 protein and a biomarker of cervical cancer progression

J Miller, A Dakic, M Spurgeon, F Saenz… - Journal of medical …, 2022 - Wiley Online Library
… We transduced HFKs with retrovirus LXSN-HPV-16 E6/E7 and grew cells beyond their …
role of telomerase in tumor progression including invasion and resistance to therapeutic drugs. …

HPV16 E7‐induced upregulation of KDM2A promotes cervical cancer progression by regulating miR‐132–radixin pathway

R Ou, L Zhu, L Zhao, W Li, F Tao, Y Lu… - Journal of Cellular …, 2019 - Wiley Online Library
… -positive cancer cells and contributes to their apoptotic resistance. … also upregulates RDX
protein level in vitro (Figure 6c). To … its level in HPV16-positive cervical cancer tissues and pair …

[HTML][HTML] Radiation response of cervical cancer stem cells is associated with pretreatment proportion of these cells and physical status of HPV DNA

I Zamulaeva, E Selivanova, O Matchuk… - International journal of …, 2021 - mdpi.com
… At the same time, standard samples with known concentrations of HPV 16/18 DNA and β-globin
DNA were amplified in each experiment, and the number of genomic equivalents of E7, …

[HTML][HTML] Rab12 promotes radioresistance of HPV-positive cervical cancer cells by increasing G2/M arrest

Y Huang, Y Tian, W Zhang, R Liu, W Zhang - Frontiers in Oncology, 2021 - frontiersin.org
… measured Rab12 protein levels in several cervical cancer cell … Rab12 protein was highly
expressed in cervical cancer cells. … cervical cancer cells SiHa and HeLa are more resistant to …

[HTML][HTML] HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression

C Hu, T Liu, C Han, Y Xuan, D Jiang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… Mechanistically, we found that E6/E7 proteins regulate the … target of HPV16 E6/E7 and is
associated with tumor stage in … of CC, but radiation resistance inevitably develops 35 . HPV …

Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer

M Ghanaat, NH Goradel, A Arashkia… - Acta Pharmacologica …, 2021 - nature.com
… to deplete HPV16 E6 and E7 oncoproteins in cervical cancer … A combination of M5 with
radiation led to synergic antitumor … E6-expressing cervical cancer cells are moderately resistant to …

Sustained expression of HPV16 E7 oncoprotein promotes p-AKT(Ser473)/p-Src(Tyr527) signaling to drive precancerous lesions to invasive cervical cancer

Z Lin, Y Zhao, Q Li, X Ci, X Ye, G Chen, Q Tu… - …, 2022 - academic.oup.com
… that HPV16 E7 mRNA was expressed in cervical cancer … HPV E7 oncoprotein could be
detected in cervical carcinomas … that E7 protein was highly expressed in HPV16 E7-positive …