CENPM upregulation by E5 oncoprotein of human papillomavirus promotes radiosensitivity in head and neck squamous cell carcinoma

T Liu, L Ma, L Song, B Yan, S Zhang, B Wang, N Zuo… - Oral Oncology, 2022 - Elsevier
… and revealed that the Centromere Protein M (CENPM) … of HPV16 E5, E6, E6* (a splicing
isoform of E6), or E7 in HPV-… that cells became more resistance to radiation, while the proportion …

… review on cross-talk of human papilloma virus oncoproteins and developmental/self-renewal pathways during the pathogenesis of uterine cervical cancer

A Ahmad, IA Ansari - Current Molecular Medicine, 2021 - ingentaconnect.com
… radio- and drug-resistant cervical cancer. Therefore, this review … in the attainment of
radioresistance in cervical cancer [74]. A … Selective targeting of HPV16 E6/E7 in cervical cancer

Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer

N Salomon, A Selmi, C Grunwitz, A Kong… - Cancer Immunology …, 2022 - Springer
… The HPV E6 and E7 proteins are oncogenic drivers and thus … E7 RNA-LPX synergizes with
LRT in HPV16 + mouse tumors, … characterized radiation-mediated effects on the local tumor

Association Between E6 and E7 Human Papilloma Virus Type 16 Oncogen Mutations and P21 Protein Expression in Cervical Cancer

INB Mahendra, ING Budiana, MS Jaya… - … Journal of Medical …, 2023 - ej-med.org.ejece.org
… Increased HOTAIR could induce radio-resistance by inhibiting p21 protein in … of E6 and E7
HPV16/18 was associated with the expression of TMPOP2 in CaSki and HeLa cervical cancer

NRF2, p53, and p16: predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy

PS Ramesh, D Devegowda, A Singh… - Critical reviews in …, 2020 - Elsevier
… Beyond any doubt, HPV infection prominently HPV16 (… ve cervical cancer cell lines and
inhibited the growth of tumor … of HPV +ve cancer cells to the combined treatment of irradiation and …

HPV16 E5 mediates resistance to PD-L1 blockade and can be targeted with rimantadine in head and neck cancer

S Miyauchi, PD Sanders, K Guram, SS Kim, F Paolini… - Cancer research, 2020 - AACR
… of overall cancer worldwide including cervical cancer and head … whether radiation combined
with CBI could enhance local tumor … of HPV viral proteins. Although the functions of HPV …

TP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer

I Kuno, D Takayanagi, Y Asami, N Murakami… - Scientific Reports, 2021 - nature.com
E6 and E7 proteins form complexes with p53 and … radioresistance or poor prognosis in
cervical cancer. In our study, patients without HPV16/18 had poorer PFS than those with HPV16/…

RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis

SM Gupta, J Mania-Pramanik - Journal of biomedical science, 2019 - Springer
Cervical cancer is the fourth most frequent cancer in women … Of these, HPV16 and
HPV18 are the most important types, … All these molecular alterations facilitate resistance to …

[HTML][HTML] Significant growth inhibition by a bispecific affibody targeting oncoprotein E7 in both HPV16 and 18 positive cervical cancer in vitro and in vivo

X Tan, J Yang, J Jiang, W Wang, J Ren, Q Li… - European Journal of …, 2022 - Elsevier
… To clarify the molecular mechanisms through which affibodies target the protein E7 to inhibit
the growth of cervical cancer cells, we first confirmed the binding specificity of affibodies to …

The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

JA Scarth, MR Patterson… - Journal of General …, 2021 - microbiologyresearch.org
… Indeed, the majority of HPV16-associated cervical cancer … to ultraviolet (UV)-B radiation;
this requires E5-dependent … the E7 protein in high-grade cervical neoplasia and cervical