DNMT1 enhances the radiosensitivity of HPV-positive head and neck squamous cell carcinomas via downregulating SMG1

C Zhang, J Mi, Y Deng, Z Deng, D Long… - OncoTargets and …, 2020 - Taylor & Francis
… shown that E6 and E7 can also bind to other proteins, such as … Citation16 However, the
separate expression of E6 and E7 is … Figure 2 HPV-16 E6 promotes the sensitivity of radiation in …

siRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: an in vitro study on anti-cancer combination therapy

P Shiri Aghbash, N Hemmat, B Baradaran… - European Journal of …, 2023 - Springer
… , such as p53 and retinoblastoma protein [3]. Given the role … accompanied by chemotherapy
or radiation therapy [3]. … reduce drug resistance in the treatment of cervical cancer. However, …

[HTML][HTML] Cervical cancer therapies: Current challenges and future perspectives

CA Burmeister, SF Khan, G Schäfer, N Mbatani… - Tumour Virus …, 2022 - Elsevier
… of HPV 16- and 100% of HPV 18-positive cervical carcinomas … of radiation therapy currently
used to treat cervical cancer … to target mechanisms of tumour drug resistance as this is a key …

Biology of HPV mediated carcinogenesis and tumor progression

PF Cosper, S Bradley, Q Luo, RJ Kimple - Seminars in radiation oncology, 2021 - Elsevier
cervical cancer and is associated with increased E6 and E7 … by the expression of HPV16 E6
and E7 oncogenes. Similarly, … to immune evasion and treatment resistance. More research is …

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response

J Sitz, SA Blanchet, SF Gameiro… - Proceedings of the …, 2019 - National Acad Sciences
… that recombinant GST-HPV16 E7 protein efficiently pulled down … Interestingly, we observed
that the total number of radiation-… that cervical cancer cells that express E6 and E7 exhibit …

Fused toes homolog, a potential molecular regulator of human papillomavirus type 16 E6 and E7 oncoproteins in cervical cancer

P DS, PK Chaturvedi, D Krishnamoorthy, YS Seo… - Plos one, 2022 - journals.plos.org
… , invasive properties, and radiation resistance [5, 6]. Furthermore, … effects of FTS on HPV16
E6 and E7 in cervical cancer. … and the E6 and E7 proteins through collaborative regulation in …

Gene targeting of HPV18 E6 and E7 synchronously by nonviral transfection of CRISPR/Cas9 system in cervical cancer

K Ling, L Yang, N Yang, M Chen, Y Wang… - Human gene …, 2020 - liebertpub.com
… The HPV18-positive HeLa and HPV16-positive SiHa cervical cancer cell lines were …
This study performed western blotting to detect the protein expression levels of E6, E7, P53, …

[HTML][HTML] The research progress on radiation resistance of cervical cancer

M Liang, L Sheng, Y Ke, Z Wu - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
… of radiation sensitivity in cervical cancer (A) HPV16/18 reduced the radiosensitivity of … (B)
Overexpression of ZNF582 protein could enhance the radioresistance of cervical cancer cells. (…

Human papillomavirus 16 promotes microhomology-mediated end-joining

JE Leeman, Y Li, A Bell, SS Hussain… - Proceedings of the …, 2019 - National Acad Sciences
cervical cancer, anal cancer, penile cancer, and vulvar … Furthermore, we find that HPV16-E7
expression alone promotes … radiation in U2OS cells stably transfected with an HPV16 E7-…

Human papillomavirus E7 protein induces homologous recombination defects and PARPi sensitivity

S He, A Wang, J Wang, Z Tang, X Wang… - Journal of Cancer …, 2024 - Springer
E6 and E7 genes of HPV16 subtype, which were transfected into HEK293T cells in parallel
with empty vector (Fig. 2A). In ionizing radiation (IR, 10 Gy)-treated cells, E7cervical cancer