High-risk human papillomavirus E7 maintains stemness via APH1B in cervical cancer stem-cell like cells

S Yang, T Chen, L Huang, S Xu, Z Cao… - Cancer Management …, 2019 - Taylor & Francis
HPV16 E7 in SiHa sphere cells and overexpressed HPV16 … overexpression of early viral
protein E6 and E7 of HR-HPV is … , self-renewal, and drug resistance. We then knocked down …

A review on the role of epidermal growth factor signaling in the development, progression and treatment of cervical cancer

S Muthusami, R Sabanayagam, L Periyasamy… - International Journal of …, 2022 - Elsevier
… A functional EGF signaling is involved in the HPV16 viral entry … and chemo/radio-resistance
upon irradiation (IR)/treatment with … The expression of a similar oncogenic protein fused toes …

The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers

VL Porter, MA Marra - Cancers, 2022 - mdpi.com
… that expression of E6 and E7 from either HPV16 or HPV18 is … The inhibition of DDR
proteins in cervical cancer and HPV-… , and sensitize the tumours to radiation and cisplatin [206]. …

The value of CXCL1, CXCL2, CXCL3, and CXCL8 as potential prognosis markers in cervical cancer: evidence of E6/E7 from HPV16 and 18 in chemokines regulation

L Fernandez-Avila, AM Castro-Amaya… - Biomedicines, 2023 - mdpi.com
… are the inactivation of the tumor suppressor proteins p53 and pRB [16,… E6 and the
membrane-associated guanylate kinase proteins (E6/MAGUK) [19,20] and the suppression effect of …

Dysregulation of stemness pathways in HPV mediated cervical malignant transformation identifies potential oncotherapy targets

M Budhwani, SW Lukowski, SV Porceddu… - Frontiers in Cellular …, 2020 - frontiersin.org
… In this perspective, we discuss evidence of a cervical cancer stem … In a transgenic mouse
model expressing HPV16 E7 under the … Both of these proteins are involved in cellular adhesion, …

A critical role for p53 during the HPV16 life cycle

CT Fontan, CD James, AT Prabhakar… - Microbiology …, 2022 - Am Soc Microbiol
proteins from high-risk HPVs can bind to p53 and this interaction can trigger apoptosis in
cervical cancer … the fact that episomal HPV16 genomes are resistant to exonuclease digestion) (…

Estrogen attenuates the growth of human papillomavirus-positive epithelial cells

ML Bristol, CD James, X Wang, CT Fontan, IM Morgan - Msphere, 2020 - Am Soc Microbiol
… of cervical cancer in a K14-HPV16 E7 transgenic mouse … we demonstrate that estrogen plus
radiation treatment of the HPV+… analyzed the protein levels of p53 and pRb in our cancer cell …

Interaction between cigarette smoke and human papillomavirus 16 E6/E7 oncoproteins to induce SOD2 expression and DNA damage in head and neck cancer

D Carrillo-Beltrán, JC Osorio, R Blanco, C Oliva… - International Journal of …, 2023 - mdpi.com
… (cervical cancer cell line containing two copies of HPV16 per … chemotherapy, SOD2
overexpression increases resistance to … transcripts and protein in HPV16 E6, and E7 transduced …

Human papillomavirus 16 infection alters the Toll-like receptors and downstream signaling cascade: A plausible early event in cervical squamous cell carcinoma …

C Guleria, V Suri, R Kapoor, RW Minz, R Aggarwal - Gynecologic Oncology, 2019 - Elsevier
… HPV is a known etiological factor of cervical cancer and is known to … HPV 16 infected cervical
carcinoma … innate immune response in carcinoma cervix, the protein expression of IL-10 …

Human papillomavirus 16 E2 regulates keratinocyte gene expression relevant to cancer and the viral life cycle

MR Evans, CD James, ML Bristol, TJ Nulton… - Journal of …, 2019 - Am Soc Microbiol
… The HPV16 E2 protein regulates host gene expression in … head and neck cancer cell line
resistant to radiation treatment (… of HPV16 + HNC and other HPV16 tumors to radiation therapy. …